Assay Detail
Functional
CHEMBL905036
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Inhibition of 10.0 ug/mL collagen-induced platelet aggregation in human platelet rich plasma
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Tissue | Plasma |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and in vitro antiplatelet activity of new 4-(1-piperazinyl)coumarin derivatives. Human platelet phosphodiesterase 3 inhibitory properties of the two most effective compounds described and molecular modeling study on their interactions with phosphodiesterase 3A catalytic site.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 4.33 | 4.44 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL229518 | — | — | 1 | 4.44 |
| CHEMBL229619 | — | — | 1 | 4.22 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL229518 | — | IC50 | = | 36000.0 | nM | 4.44 |
| CHEMBL229619 | — | IC50 | = | 60000.0 | nM | 4.22 |