Assay Detail
Binding
CHEMBL905040
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Inhibition of human platelet PDE3
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
Synthesis and in vitro antiplatelet activity of new 4-(1-piperazinyl)coumarin derivatives. Human platelet phosphodiesterase 3 inhibitory properties of the two most effective compounds described and molecular modeling study on their interactions with phosphodiesterase 3A catalytic site.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 6.94 | 7.43 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL229417 | — | — | 1 | 7.43 |
| CHEMBL228776 | — | — | 1 | 7.11 |
| CHEMBL189 | MILRINONE | 4.0 | 1 | 6.68 |
| CHEMBL799 | CILOSTAZOL | 4.0 | 1 | 6.55 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL229417 | — | IC50 | = | 37.0 | nM | 7.43 |
| CHEMBL228776 | — | IC50 | = | 78.0 | nM | 7.11 |
| CHEMBL189 | MILRINONE | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL799 | CILOSTAZOL | IC50 | = | 280.0 | nM | 6.55 |