Assay Detail
Binding
CHEMBL905158
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Inhibition of human aromatase
24
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Synthesis and biological evaluation of (+/-)-abyssinone II and its analogues as aromatase inhibitors for chemoprevention of breast cancer.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 24 | 5.04 | 6.57 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL488 | AMINOGLUTETHIMIDE | 4.0 | 1 | 6.57 |
| CHEMBL229908 | LIQUIRITIGENIN DIMETHYL ETHER | — | 1 | 5.73 |
| CHEMBL229635 | — | — | 1 | 5.43 |
| CHEMBL229789 | — | — | 1 | 5.39 |
| CHEMBL229906 | — | — | 1 | 5.33 |
| CHEMBL388374 | — | — | 1 | 5.32 |
| CHEMBL425670 | — | — | 1 | 5.12 |
| CHEMBL1162951 | — | — | 1 | 4.92 |
| CHEMBL229945 | — | — | 1 | 4.86 |
| CHEMBL229790 | — | — | 1 | 4.60 |
| CHEMBL228985 | — | — | 1 | 4.54 |
| CHEMBL558103 | ABYSSINONE II | — | 1 | 4.39 |
| CHEMBL229094 | — | — | 1 | 4.26 |
| CHEMBL389925 | — | — | 1 | 4.08 |
| CHEMBL390731 | — | — | 1 | - |
| CHEMBL229885 | LICOAGROCHALCONE A | — | 1 | - |
| CHEMBL229893 | — | — | 1 | - |
| CHEMBL229907 | — | — | 1 | - |
| CHEMBL229841 | — | — | 1 | - |
| CHEMBL229944 | — | — | 1 | - |
| CHEMBL229633 | — | — | 1 | - |
| CHEMBL390364 | — | — | 1 | - |
| CHEMBL388375 | — | — | 1 | - |
| CHEMBL229905 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL488 | AMINOGLUTETHIMIDE | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL229908 | LIQUIRITIGENIN DIMETHYL ETHER | IC50 | = | 1860.0 | nM | 5.73 |
| CHEMBL229635 | — | IC50 | = | 3670.0 | nM | 5.43 |
| CHEMBL229789 | — | IC50 | = | 4080.0 | nM | 5.39 |
| CHEMBL229906 | — | IC50 | = | 4670.0 | nM | 5.33 |
| CHEMBL388374 | — | IC50 | = | 4750.0 | nM | 5.32 |
| CHEMBL425670 | — | IC50 | = | 7670.0 | nM | 5.12 |
| CHEMBL1162951 | — | IC50 | = | 12100.0 | nM | 4.92 |
| CHEMBL229945 | — | IC50 | = | 13950.0 | nM | 4.86 |
| CHEMBL229790 | — | IC50 | = | 25140.0 | nM | 4.60 |
| CHEMBL228985 | — | IC50 | = | 28650.0 | nM | 4.54 |
| CHEMBL558103 | ABYSSINONE II | IC50 | = | 40950.0 | nM | 4.39 |
| CHEMBL229094 | — | IC50 | = | 54670.0 | nM | 4.26 |
| CHEMBL389925 | — | IC50 | = | 82940.0 | nM | 4.08 |
| CHEMBL390731 | — | IC50 | > | 261500.0 | nM | - |
| CHEMBL229885 | LICOAGROCHALCONE A | IC50 | > | 308300.0 | nM | - |
| CHEMBL229893 | — | IC50 | > | 261500.0 | nM | - |
| CHEMBL229907 | — | IC50 | > | 351700.0 | nM | - |
| CHEMBL229841 | — | IC50 | > | 295500.0 | nM | - |
| CHEMBL229944 | — | IC50 | > | 242400.0 | nM | - |
| CHEMBL229633 | — | IC50 | > | 283750.0 | nM | - |
| CHEMBL390364 | — | IC50 | > | 271400.0 | nM | - |
| CHEMBL388375 | — | IC50 | > | 310170.0 | nM | - |
| CHEMBL229905 | — | IC50 | > | 310200.0 | nM | - |