Assay Detail
Binding
CHEMBL905182
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]DPDPE from human delta opioid receptor expressed in HN9.10 cells
18
Total Activities
10
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Design, synthesis, and biological evaluation of novel bifunctional C-terminal-modified peptides for delta/mu opioid receptor agonists and neurokinin-1 receptor antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 10 | 8.08 | 8.89 |
| IC50 | 8 | 7.58 | 8.42 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL340032 | DADLE | — | 1 | 8.89 |
| CHEMBL439019 | — | — | 2 | 8.74 |
| CHEMBL200199 | BIPHALIN | — | 1 | 8.59 |
| CHEMBL389652 | — | — | 2 | 8.55 |
| CHEMBL229280 | — | — | 2 | 8.32 |
| CHEMBL389651 | — | — | 2 | 8.30 |
| CHEMBL2371977 | — | — | 2 | 7.82 |
| CHEMBL426363 | — | — | 2 | 7.44 |
| CHEMBL387670 | — | — | 2 | 7.11 |
| CHEMBL2371978 | — | — | 2 | 7.03 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL340032 | DADLE | Ki | = | 1.3 | nM | 8.89 |
| CHEMBL439019 | — | Ki | = | 1.8 | nM | 8.74 |
| CHEMBL200199 | BIPHALIN | Ki | = | 2.6 | nM | 8.59 |
| CHEMBL389652 | — | Ki | = | 2.8 | nM | 8.55 |
| CHEMBL439019 | — | IC50 | = | 3.802 | nM | 8.42 |
| CHEMBL229280 | — | Ki | = | 4.8 | nM | 8.32 |
| CHEMBL389651 | — | Ki | = | 5.0 | nM | 8.30 |
| CHEMBL389652 | — | IC50 | = | 6.026 | nM | 8.22 |
| CHEMBL389651 | — | IC50 | = | 10.72 | nM | 7.97 |
| CHEMBL229280 | — | IC50 | = | 12.02 | nM | 7.92 |
| CHEMBL2371977 | — | Ki | = | 15.0 | nM | 7.82 |
| CHEMBL2371977 | — | IC50 | = | 31.62 | nM | 7.50 |
| CHEMBL426363 | — | Ki | = | 36.0 | nM | 7.44 |
| CHEMBL426363 | — | IC50 | = | 77.62 | nM | 7.11 |
| CHEMBL387670 | — | Ki | = | 77.0 | nM | 7.11 |
| CHEMBL2371978 | — | Ki | = | 93.0 | nM | 7.03 |
| CHEMBL387670 | — | IC50 | = | 162.18 | nM | 6.79 |
| CHEMBL2371978 | — | IC50 | = | 199.53 | nM | 6.70 |