Assay Detail
Binding
CHEMBL905727
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Inhibition of HCV NS3 protease in presence of pH 7.5 HEPES buffer
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Hepatitis C virus |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Evaluation of a diverse set of potential P1 carboxylic acid bioisosteres in hepatitis C virus NS3 protease inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 16 | 7.18 | 10.24 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL414993 | — | — | 1 | 10.24 |
| CHEMBL229689 | — | — | 1 | 9.66 |
| CHEMBL414994 | — | — | 1 | 9.47 |
| CHEMBL229632 | — | — | 1 | 8.22 |
| CHEMBL389932 | — | — | 1 | 8.05 |
| CHEMBL222385 | — | — | 1 | 7.70 |
| CHEMBL414992 | — | — | 1 | 6.85 |
| CHEMBL387965 | — | — | 1 | 6.67 |
| CHEMBL390164 | — | — | 1 | 6.37 |
| CHEMBL375957 | — | — | 1 | 6.25 |
| CHEMBL387963 | — | — | 1 | 6.09 |
| CHEMBL375959 | — | — | 1 | 6.06 |
| CHEMBL442052 | — | — | 1 | 5.96 |
| CHEMBL388332 | — | — | 1 | 5.80 |
| CHEMBL436980 | — | — | 1 | 5.77 |
| CHEMBL387964 | — | — | 1 | 5.66 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL414993 | — | Ki | = | 0.058 | nM | 10.24 |
| CHEMBL229689 | — | Ki | = | 0.22 | nM | 9.66 |
| CHEMBL414994 | — | Ki | = | 0.34 | nM | 9.47 |
| CHEMBL229632 | — | Ki | = | 6.0 | nM | 8.22 |
| CHEMBL389932 | — | Ki | = | 9.0 | nM | 8.05 |
| CHEMBL222385 | — | Ki | = | 20.0 | nM | 7.70 |
| CHEMBL414992 | — | Ki | = | 140.0 | nM | 6.85 |
| CHEMBL387965 | — | Ki | = | 214.0 | nM | 6.67 |
| CHEMBL390164 | — | Ki | = | 425.0 | nM | 6.37 |
| CHEMBL375957 | — | Ki | = | 560.0 | nM | 6.25 |
| CHEMBL387963 | — | Ki | = | 821.0 | nM | 6.09 |
| CHEMBL375959 | — | Ki | = | 880.0 | nM | 6.06 |
| CHEMBL442052 | — | Ki | = | 1100.0 | nM | 5.96 |
| CHEMBL388332 | — | Ki | = | 1600.0 | nM | 5.80 |
| CHEMBL436980 | — | Ki | = | 1690.0 | nM | 5.77 |
| CHEMBL387964 | — | Ki | = | 2200.0 | nM | 5.66 |