Assay Detail
Functional
CHEMBL905858
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Antitumor activity against mouse CT26 cells
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | CT26 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of [7-(2,6-dichlorophenyl)-5-methylbenzo [1,2,4]triazin-3-yl]-[4-(2-pyrrolidin-1-ylethoxy)phenyl]amine--a potent, orally active Src kinase inhibitor with anti-tumor activity in preclinical assays.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 5.56 | 6.12 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL230686 | — | — | 1 | 6.12 |
| CHEMBL436137 | — | — | 1 | 5.64 |
| CHEMBL437004 | — | — | 1 | 5.62 |
| CHEMBL231235 | — | — | 1 | 5.62 |
| CHEMBL218102 | — | — | 1 | 5.60 |
| CHEMBL230614 | — | — | 1 | 5.18 |
| CHEMBL230719 | — | — | 1 | 5.17 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL230686 | — | IC50 | = | 750.0 | nM | 6.12 |
| CHEMBL436137 | — | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL437004 | — | IC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL231235 | — | IC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL218102 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL230614 | — | IC50 | = | 6600.0 | nM | 5.18 |
| CHEMBL230719 | — | IC50 | = | 6700.0 | nM | 5.17 |