Assay Detail
Binding
CHEMBL905885
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Inhibition at human JNK1 at 1uM
38
Total Activities
38
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Discovery of a new class of 4-anilinopyrimidines as potent c-Jun N-terminal kinase inhibitors: Synthesis and SAR studies.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 38 | 6.74 | 8.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL242237 | — | — | 1 | 8.05 |
| CHEMBL243750 | — | — | 1 | 7.70 |
| CHEMBL243749 | — | — | 1 | 7.68 |
| CHEMBL243088 | — | — | 1 | 7.60 |
| CHEMBL243298 | — | — | 1 | 7.55 |
| CHEMBL243299 | — | — | 1 | 7.54 |
| CHEMBL390256 | — | — | 1 | 7.50 |
| CHEMBL242865 | — | — | 1 | 7.48 |
| CHEMBL428213 | — | — | 1 | 7.47 |
| CHEMBL243297 | — | — | 1 | 7.46 |
| CHEMBL438515 | — | — | 1 | 7.46 |
| CHEMBL394816 | — | — | 1 | 7.43 |
| CHEMBL244378 | — | — | 1 | 7.34 |
| CHEMBL244839 | — | — | 1 | 7.32 |
| CHEMBL396523 | — | — | 1 | 7.26 |
| CHEMBL388700 | — | — | 1 | 7.12 |
| CHEMBL244793 | — | — | 1 | 7.09 |
| CHEMBL244580 | — | — | 1 | 7.07 |
| CHEMBL243518 | — | — | 1 | 7.03 |
| CHEMBL243517 | — | — | 1 | 6.80 |
| CHEMBL242652 | — | — | 1 | 6.73 |
| CHEMBL396766 | — | — | 1 | 6.69 |
| CHEMBL243519 | — | — | 1 | 6.56 |
| CHEMBL244626 | — | — | 1 | 6.52 |
| CHEMBL242651 | — | — | 1 | 6.41 |
| CHEMBL244628 | — | — | 1 | 6.40 |
| CHEMBL396731 | — | — | 1 | 6.16 |
| CHEMBL242702 | — | — | 1 | 6.16 |
| CHEMBL244581 | — | — | 1 | 6.15 |
| CHEMBL242701 | — | — | 1 | 5.96 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL242237 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL243750 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL243749 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL243088 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL243298 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL243299 | — | IC50 | = | 29.0 | nM | 7.54 |
| CHEMBL390256 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL242865 | — | IC50 | = | 33.0 | nM | 7.48 |
| CHEMBL428213 | — | IC50 | = | 34.0 | nM | 7.47 |
| CHEMBL243297 | — | IC50 | = | 35.0 | nM | 7.46 |
| CHEMBL438515 | — | IC50 | = | 35.0 | nM | 7.46 |
| CHEMBL394816 | — | IC50 | = | 37.0 | nM | 7.43 |
| CHEMBL244378 | — | IC50 | = | 46.0 | nM | 7.34 |
| CHEMBL244839 | — | IC50 | = | 48.0 | nM | 7.32 |
| CHEMBL396523 | — | IC50 | = | 55.0 | nM | 7.26 |
| CHEMBL388700 | — | IC50 | = | 76.0 | nM | 7.12 |
| CHEMBL244793 | — | IC50 | = | 82.0 | nM | 7.09 |
| CHEMBL244580 | — | IC50 | = | 85.0 | nM | 7.07 |
| CHEMBL243518 | — | IC50 | = | 93.0 | nM | 7.03 |
| CHEMBL243517 | — | IC50 | = | 157.0 | nM | 6.80 |
| CHEMBL242652 | — | IC50 | = | 186.0 | nM | 6.73 |
| CHEMBL396766 | — | IC50 | = | 204.0 | nM | 6.69 |
| CHEMBL243519 | — | IC50 | = | 278.0 | nM | 6.56 |
| CHEMBL244626 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL242651 | — | IC50 | = | 391.0 | nM | 6.41 |
| CHEMBL244628 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL396731 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL242702 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL244581 | — | IC50 | = | 705.0 | nM | 6.15 |
| CHEMBL242701 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL242488 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL242489 | — | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL394869 | — | IC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL244629 | — | IC50 | = | 15400.0 | nM | 4.81 |
| CHEMBL244627 | — | IC50 | = | 18200.0 | nM | 4.74 |
| CHEMBL396487 | — | IC50 | = | 44700.0 | nM | 4.35 |
| CHEMBL396730 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL394870 | — | IC50 | > | 100000.0 | nM | - |