Assay Detail
Functional
CHEMBL905886
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of TNF-alpha-stimulated phosphorylation of c-Jun in HepG2 cells
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HepG2 |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Discovery of a new class of 4-anilinopyrimidines as potent c-Jun N-terminal kinase inhibitors: Synthesis and SAR studies.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 5.60 | 6.23 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL428213 | — | — | 1 | 6.23 |
| CHEMBL242237 | — | — | 1 | 5.91 |
| CHEMBL242488 | — | — | 1 | 4.65 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL428213 | — | IC50 | = | 590.0 | nM | 6.23 |
| CHEMBL242237 | — | IC50 | = | 1220.0 | nM | 5.91 |
| CHEMBL242488 | — | IC50 | = | 22300.0 | nM | 4.65 |