Assay Detail
Functional
CHEMBL905928
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of MCP1-stimulated chemotaxis in monocytes transfected with human CCR2
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Alpha-aminothiazole-gamma-aminobutanoic amides as potent, small molecule CCR2 receptor antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 8.45 | 9.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL438304 | — | — | 1 | 9.22 |
| CHEMBL388487 | — | — | 1 | 9.15 |
| CHEMBL397996 | — | — | 1 | 9.15 |
| CHEMBL230281 | — | — | 1 | 8.74 |
| CHEMBL397948 | — | — | 1 | 8.28 |
| CHEMBL388867 | — | — | 1 | 7.57 |
| CHEMBL398150 | — | — | 1 | 7.06 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL438304 | — | IC50 | = | 0.6 | nM | 9.22 |
| CHEMBL388487 | — | IC50 | = | 0.7 | nM | 9.15 |
| CHEMBL397996 | — | IC50 | = | 0.7 | nM | 9.15 |
| CHEMBL230281 | — | IC50 | = | 1.8 | nM | 8.74 |
| CHEMBL397948 | — | IC50 | = | 5.3 | nM | 8.28 |
| CHEMBL388867 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL398150 | — | IC50 | = | 87.0 | nM | 7.06 |