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Assay Detail

CHEMBL906053

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of HCV recombinant NS5B polymerase
29
Total Activities
29
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Hepatitis C virus
Confidence 0 — Uncurated / Unknown
Curated By Autocuration

Target

Unchecked (CHEMBL612545)
Type UNCHECKED

Publication

Isothiazoles as active-site inhibitors of HCV NS5B polymerase.
Yan S, Appleby T, Gunic E, Shim JH, Tasu T, Kim H, Rong F, Chen H, Hamatake R, Wu JZ, Hong Z, Yao N.
Bioorg Med Chem Lett (2007) 17 : 28 -33
PubMed 17049853 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 29 5.53 6.70

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL212474 1 6.70
CHEMBL230452 1 6.52
CHEMBL388041 1 6.52
CHEMBL230027 1 6.52
CHEMBL231390 1 6.30
CHEMBL385820 1 6.16
CHEMBL230451 1 6.05
CHEMBL389603 1 6.00
CHEMBL231489 1 5.92
CHEMBL231406 1 5.92
CHEMBL230555 1 5.89
CHEMBL231597 1 5.85
CHEMBL390242 1 5.82
CHEMBL396492 1 5.77
CHEMBL231598 1 5.75
CHEMBL230144 1 5.75
CHEMBL390039 1 5.70
CHEMBL388040 1 5.46
CHEMBL231402 1 5.33
CHEMBL387834 1 5.23
CHEMBL231490 1 5.19
CHEMBL230632 1 5.08
CHEMBL231596 1 5.01
CHEMBL390243 1 5.01
CHEMBL231498 1 4.48
CHEMBL231506 1 4.36
CHEMBL211488 1 4.00
CHEMBL228480 1 4.00
CHEMBL269552 1 4.00

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL212474 IC50 = 200.0 nM 6.70
CHEMBL230452 IC50 = 300.0 nM 6.52
CHEMBL388041 IC50 = 300.0 nM 6.52
CHEMBL230027 IC50 = 300.0 nM 6.52
CHEMBL231390 IC50 = 500.0 nM 6.30
CHEMBL385820 IC50 = 700.0 nM 6.16
CHEMBL230451 IC50 = 900.0 nM 6.05
CHEMBL389603 IC50 = 1000.0 nM 6.00
CHEMBL231489 IC50 = 1200.0 nM 5.92
CHEMBL231406 IC50 = 1200.0 nM 5.92
CHEMBL230555 IC50 = 1300.0 nM 5.89
CHEMBL231597 IC50 = 1400.0 nM 5.85
CHEMBL390242 IC50 = 1500.0 nM 5.82
CHEMBL396492 IC50 = 1700.0 nM 5.77
CHEMBL231598 IC50 = 1800.0 nM 5.75
CHEMBL230144 IC50 = 1800.0 nM 5.75
CHEMBL390039 IC50 = 2000.0 nM 5.70
CHEMBL388040 IC50 = 3500.0 nM 5.46
CHEMBL231402 IC50 = 4700.0 nM 5.33
CHEMBL387834 IC50 = 5900.0 nM 5.23
CHEMBL231490 IC50 = 6400.0 nM 5.19
CHEMBL230632 IC50 = 8300.0 nM 5.08
CHEMBL231596 IC50 = 9700.0 nM 5.01
CHEMBL390243 IC50 = 9700.0 nM 5.01
CHEMBL231498 IC50 = 33000.0 nM 4.48
CHEMBL231506 IC50 = 44000.0 nM 4.36
CHEMBL211488 IC50 = 100000.0 nM 4.00
CHEMBL228480 IC50 = 100000.0 nM 4.00
CHEMBL269552 IC50 = 100000.0 nM 4.00