Assay Detail
Functional
CHEMBL906054
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Antiviral activity against Hepatitis C virus by cell based replicon assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Hepacivirus hominis |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Isothiazoles as active-site inhibitors of HCV NS5B polymerase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 6 | 6.06 | 7.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL212474 | — | — | 1 | 7.00 |
| CHEMBL230452 | — | — | 1 | 6.66 |
| CHEMBL231406 | — | — | 1 | 5.96 |
| CHEMBL387834 | — | — | 1 | 5.70 |
| CHEMBL230451 | — | — | 1 | 5.54 |
| CHEMBL231390 | — | — | 1 | 5.47 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL212474 | — | EC50 | = | 100.0 | nM | 7.00 |
| CHEMBL230452 | — | EC50 | = | 220.0 | nM | 6.66 |
| CHEMBL231406 | — | EC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL387834 | — | EC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL230451 | — | EC50 | = | 2900.0 | nM | 5.54 |
| CHEMBL231390 | — | EC50 | = | 3400.0 | nM | 5.47 |