Assay Detail
Binding
CHEMBL906385
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Inhibition of HCV NS5B polymerase
26
Total Activities
26
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Hepatitis C virus |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Further studies on hepatitis C virus NS5B RNA-dependent RNA polymerase inhibitors toward improved replicon cell activities: benzimidazole and structurally related compounds bearing the 2-morpholinophenyl moiety.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 26 | 7.14 | 8.14 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL396105 | — | — | 1 | 8.14 |
| CHEMBL245328 | — | — | 1 | 8.14 |
| CHEMBL245327 | — | — | 1 | 8.00 |
| CHEMBL210297 | — | — | 1 | 7.77 |
| CHEMBL245329 | — | — | 1 | 7.72 |
| CHEMBL245326 | — | — | 1 | 7.52 |
| CHEMBL390883 | — | — | 1 | 7.38 |
| CHEMBL245325 | — | — | 1 | 7.32 |
| CHEMBL392034 | — | — | 1 | 7.29 |
| CHEMBL397318 | — | — | 1 | 7.18 |
| CHEMBL246975 | — | — | 1 | 7.17 |
| CHEMBL394388 | — | — | 1 | 7.16 |
| CHEMBL245763 | — | — | 1 | 7.15 |
| CHEMBL245765 | — | — | 1 | 7.05 |
| CHEMBL396336 | — | — | 1 | 7.00 |
| CHEMBL246974 | — | — | 1 | 7.00 |
| CHEMBL396854 | — | — | 1 | 6.96 |
| CHEMBL396562 | — | — | 1 | 6.89 |
| CHEMBL436823 | — | — | 1 | 6.89 |
| CHEMBL246985 | — | — | 1 | 6.82 |
| CHEMBL246566 | — | — | 1 | 6.82 |
| CHEMBL396837 | — | — | 1 | 6.75 |
| CHEMBL397604 | — | — | 1 | 6.64 |
| CHEMBL246775 | — | — | 1 | 6.58 |
| CHEMBL397605 | — | — | 1 | 6.39 |
| CHEMBL397606 | — | — | 1 | 6.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL396105 | — | IC50 | = | 7.2 | nM | 8.14 |
| CHEMBL245328 | — | IC50 | = | 7.2 | nM | 8.14 |
| CHEMBL245327 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL210297 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL245329 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL245326 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL390883 | — | IC50 | = | 42.0 | nM | 7.38 |
| CHEMBL245325 | — | IC50 | = | 48.0 | nM | 7.32 |
| CHEMBL392034 | — | IC50 | = | 51.0 | nM | 7.29 |
| CHEMBL397318 | — | IC50 | = | 66.0 | nM | 7.18 |
| CHEMBL246975 | — | IC50 | = | 68.0 | nM | 7.17 |
| CHEMBL394388 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL245763 | — | IC50 | = | 71.0 | nM | 7.15 |
| CHEMBL245765 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL396336 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL246974 | — | IC50 | = | 99.0 | nM | 7.00 |
| CHEMBL396854 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL396562 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL436823 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL246985 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL246566 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL396837 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL397604 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL246775 | — | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL397605 | — | IC50 | = | 410.0 | nM | 6.39 |
| CHEMBL397606 | — | IC50 | = | 1000.0 | nM | 6.00 |