Assay Detail
Functional
CHEMBL906386
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Antiviral activity against HCV in Huh-5-2 cells by replicon assay
26
Total Activities
26
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Hepacivirus hominis |
| Cell Type | Huh-5-2 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Further studies on hepatitis C virus NS5B RNA-dependent RNA polymerase inhibitors toward improved replicon cell activities: benzimidazole and structurally related compounds bearing the 2-morpholinophenyl moiety.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 26 | 6.34 | 8.12 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL245328 | — | — | 1 | 8.12 |
| CHEMBL245327 | — | — | 1 | 7.28 |
| CHEMBL396105 | — | — | 1 | 7.28 |
| CHEMBL245329 | — | — | 1 | 7.22 |
| CHEMBL245326 | — | — | 1 | 6.68 |
| CHEMBL390883 | — | — | 1 | 6.57 |
| CHEMBL397318 | — | — | 1 | 6.51 |
| CHEMBL210297 | — | — | 1 | 6.50 |
| CHEMBL392034 | — | — | 1 | 6.43 |
| CHEMBL245325 | — | — | 1 | 6.42 |
| CHEMBL246975 | — | — | 1 | 6.36 |
| CHEMBL245763 | — | — | 1 | 6.26 |
| CHEMBL245765 | — | — | 1 | 6.24 |
| CHEMBL246566 | — | — | 1 | 6.10 |
| CHEMBL394388 | — | — | 1 | 6.04 |
| CHEMBL396854 | — | — | 1 | 6.02 |
| CHEMBL396562 | — | — | 1 | 6.00 |
| CHEMBL436823 | — | — | 1 | 5.96 |
| CHEMBL396336 | — | — | 1 | 5.92 |
| CHEMBL246974 | — | — | 1 | 5.92 |
| CHEMBL246775 | — | — | 1 | 5.89 |
| CHEMBL246985 | — | — | 1 | 5.85 |
| CHEMBL397605 | — | — | 1 | 5.85 |
| CHEMBL397604 | — | — | 1 | 5.51 |
| CHEMBL396837 | — | — | 1 | 5.46 |
| CHEMBL397606 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL245328 | — | EC50 | = | 7.6 | nM | 8.12 |
| CHEMBL245327 | — | EC50 | = | 52.0 | nM | 7.28 |
| CHEMBL396105 | — | EC50 | = | 52.0 | nM | 7.28 |
| CHEMBL245329 | — | EC50 | = | 60.0 | nM | 7.22 |
| CHEMBL245326 | — | EC50 | = | 210.0 | nM | 6.68 |
| CHEMBL390883 | — | EC50 | = | 270.0 | nM | 6.57 |
| CHEMBL397318 | — | EC50 | = | 310.0 | nM | 6.51 |
| CHEMBL210297 | — | EC50 | = | 320.0 | nM | 6.50 |
| CHEMBL392034 | — | EC50 | = | 370.0 | nM | 6.43 |
| CHEMBL245325 | — | EC50 | = | 380.0 | nM | 6.42 |
| CHEMBL246975 | — | EC50 | = | 440.0 | nM | 6.36 |
| CHEMBL245763 | — | EC50 | = | 550.0 | nM | 6.26 |
| CHEMBL245765 | — | EC50 | = | 580.0 | nM | 6.24 |
| CHEMBL246566 | — | EC50 | = | 800.0 | nM | 6.10 |
| CHEMBL394388 | — | EC50 | = | 910.0 | nM | 6.04 |
| CHEMBL396854 | — | EC50 | = | 950.0 | nM | 6.02 |
| CHEMBL396562 | — | EC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL436823 | — | EC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL396336 | — | EC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL246974 | — | EC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL246775 | — | EC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL246985 | — | EC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL397605 | — | EC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL397604 | — | EC50 | = | 3100.0 | nM | 5.51 |
| CHEMBL396837 | — | EC50 | = | 3500.0 | nM | 5.46 |
| CHEMBL397606 | — | EC50 | > | 30000.0 | nM | - |