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Assay Detail

CHEMBL906489

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antiviral activity against HCMV AD169
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Human betaherpesvirus 5
Confidence 1 — Organism
Curated By Intermediate

Target

Human betaherpesvirus 5 (CHEMBL371)
Type ORGANISM
Organism Human betaherpesvirus 5

Publication

Synthesis and antiviral activity of C-fluoro-branched cyclopropyl nucleosides.
Kim A, Hong JH.
Eur J Med Chem (2007) 42 : 487 -493
PubMed 17188402 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 10 4.76 6.00

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL182 GANCICLOVIR 4.0 1 6.00
CHEMBL442796 1 4.97
CHEMBL228392 1 4.37
CHEMBL229074 1 4.29
CHEMBL388169 1 4.15
CHEMBL129 ZIDOVUDINE 4.0 1 -
CHEMBL394604 1 -
CHEMBL397433 1 -
CHEMBL228870 1 -
CHEMBL228383 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL182 GANCICLOVIR EC50 = 1010.0 nM 6.00
CHEMBL442796 EC50 = 10610.0 nM 4.97
CHEMBL228392 EC50 = 43000.0 nM 4.37
CHEMBL229074 EC50 = 51430.0 nM 4.29
CHEMBL388169 EC50 = 71000.0 nM 4.15
CHEMBL129 ZIDOVUDINE EC50 - -
CHEMBL394604 EC50 > 100000.0 nM -
CHEMBL397433 EC50 > 100000.0 nM -
CHEMBL228870 EC50 > 100000.0 nM -
CHEMBL228383 EC50 > 100000.0 nM -