Assay Detail
Binding
CHEMBL906676
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of His-tagged human p110gamma expressed in SF9/Baculovirus system by SPA
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | Sf9 |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Target
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform (CHEMBL3267) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Synthesis and biological evaluation of sulfonylhydrazone-substituted imidazo[1,2-a]pyridines as novel PI3 kinase p110alpha inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 6.50 | 7.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL556399 | — | — | 1 | 7.40 |
| CHEMBL538346 | — | — | 1 | 6.60 |
| CHEMBL541643 | — | — | 1 | 6.18 |
| CHEMBL98350 | LY-294002 | -1.0 | 1 | 5.80 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL556399 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL538346 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL541643 | — | IC50 | = | 660.0 | nM | 6.18 |
| CHEMBL98350 | LY-294002 | IC50 | = | 1600.0 | nM | 5.80 |