Assay Detail
Binding
CHEMBL906815
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Inhibition of Electrophorus electricus AChE by Ellman's method
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Electrophorus electricus |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Synthesis, in vitro assay, and molecular modeling of new piperidine derivatives having dual inhibitory potency against acetylcholinesterase and Abeta1-42 aggregation for Alzheimer's disease therapeutics.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 21 | 5.62 | 6.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL95 | TACRINE | 4.0 | 1 | 6.82 |
| CHEMBL229000 | — | — | 1 | 6.51 |
| CHEMBL229001 | — | — | 1 | 6.08 |
| CHEMBL228999 | — | — | 1 | 5.88 |
| CHEMBL229050 | — | — | 1 | 5.62 |
| CHEMBL426915 | — | — | 1 | 5.61 |
| CHEMBL389047 | — | — | 1 | 5.61 |
| CHEMBL229052 | — | — | 1 | 5.47 |
| CHEMBL229051 | — | — | 1 | 5.41 |
| CHEMBL390809 | — | — | 1 | 5.14 |
| CHEMBL229104 | — | — | 1 | 5.11 |
| CHEMBL228302 | — | — | 1 | 4.91 |
| CHEMBL228303 | — | — | 1 | 4.83 |
| CHEMBL228950 | — | — | 1 | - |
| CHEMBL228361 | — | — | 1 | - |
| CHEMBL389048 | — | — | 1 | - |
| CHEMBL229105 | — | — | 1 | - |
| CHEMBL228301 | — | — | 1 | - |
| CHEMBL389049 | — | — | 1 | - |
| CHEMBL228359 | — | — | 1 | - |
| CHEMBL228360 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL95 | TACRINE | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL229000 | — | IC50 | = | 310.0 | nM | 6.51 |
| CHEMBL229001 | — | IC50 | = | 840.0 | nM | 6.08 |
| CHEMBL228999 | — | IC50 | = | 1310.0 | nM | 5.88 |
| CHEMBL229050 | — | IC50 | = | 2410.0 | nM | 5.62 |
| CHEMBL426915 | — | IC50 | = | 2450.0 | nM | 5.61 |
| CHEMBL389047 | — | IC50 | = | 2450.0 | nM | 5.61 |
| CHEMBL229052 | — | IC50 | = | 3390.0 | nM | 5.47 |
| CHEMBL229051 | — | IC50 | = | 3890.0 | nM | 5.41 |
| CHEMBL390809 | — | IC50 | = | 7250.0 | nM | 5.14 |
| CHEMBL229104 | — | IC50 | = | 7720.0 | nM | 5.11 |
| CHEMBL228302 | — | IC50 | = | 12220.0 | nM | 4.91 |
| CHEMBL228303 | — | IC50 | = | 14780.0 | nM | 4.83 |
| CHEMBL228950 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL228361 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL389048 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL229105 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL228301 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL389049 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL228359 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL228360 | — | IC50 | > | 100000.0 | nM | - |