Assay Detail
Binding
CHEMBL906819
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Inhibition of beta amyloid protein 1-42 aggregation by thioflavin T assay
23
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Synthesis, in vitro assay, and molecular modeling of new piperidine derivatives having dual inhibitory potency against acetylcholinesterase and Abeta1-42 aggregation for Alzheimer's disease therapeutics.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 23 | 4.38 | 5.78 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL429694 | CONGO RED | -1.0 | 1 | 5.78 |
| CHEMBL229050 | — | — | 1 | 4.70 |
| CHEMBL229000 | — | — | 1 | 4.55 |
| CHEMBL229104 | — | — | 1 | 4.47 |
| CHEMBL229001 | — | — | 1 | 4.44 |
| CHEMBL389047 | — | — | 1 | 4.43 |
| CHEMBL228999 | — | — | 1 | 4.39 |
| CHEMBL390809 | — | — | 1 | 4.28 |
| CHEMBL389049 | — | — | 1 | 4.16 |
| CHEMBL228359 | — | — | 1 | 4.12 |
| CHEMBL229051 | — | — | 1 | 4.11 |
| CHEMBL228302 | — | — | 1 | 4.11 |
| CHEMBL228303 | — | — | 1 | 4.07 |
| CHEMBL502 | DONEPEZIL | 4.0 | 1 | 4.06 |
| CHEMBL229052 | — | — | 1 | 4.04 |
| CHEMBL228950 | — | — | 1 | - |
| CHEMBL426915 | — | — | 1 | - |
| CHEMBL95 | TACRINE | 4.0 | 1 | - |
| CHEMBL389048 | — | — | 1 | - |
| CHEMBL229105 | — | — | 1 | - |
| CHEMBL228301 | — | — | 1 | - |
| CHEMBL228360 | — | — | 1 | - |
| CHEMBL228361 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL429694 | CONGO RED | IC50 | = | 1650.0 | nM | 5.78 |
| CHEMBL229050 | — | IC50 | = | 20020.0 | nM | 4.70 |
| CHEMBL229000 | — | IC50 | = | 28210.0 | nM | 4.55 |
| CHEMBL229104 | — | IC50 | = | 33720.0 | nM | 4.47 |
| CHEMBL229001 | — | IC50 | = | 36330.0 | nM | 4.44 |
| CHEMBL389047 | — | IC50 | = | 37320.0 | nM | 4.43 |
| CHEMBL228999 | — | IC50 | = | 40330.0 | nM | 4.39 |
| CHEMBL390809 | — | IC50 | = | 53140.0 | nM | 4.28 |
| CHEMBL389049 | — | IC50 | = | 69400.0 | nM | 4.16 |
| CHEMBL228359 | — | IC50 | = | 74940.0 | nM | 4.12 |
| CHEMBL229051 | — | IC50 | = | 76860.0 | nM | 4.11 |
| CHEMBL228302 | — | IC50 | = | 78500.0 | nM | 4.11 |
| CHEMBL228303 | — | IC50 | = | 85920.0 | nM | 4.07 |
| CHEMBL502 | DONEPEZIL | IC50 | = | 86500.0 | nM | 4.06 |
| CHEMBL229052 | — | IC50 | = | 91960.0 | nM | 4.04 |
| CHEMBL228950 | — | IC50 | = | 105320.0 | nM | - |
| CHEMBL426915 | — | IC50 | = | 113640.0 | nM | - |
| CHEMBL95 | TACRINE | IC50 | > | 150000.0 | nM | - |
| CHEMBL389048 | — | IC50 | > | 150000.0 | nM | - |
| CHEMBL229105 | — | IC50 | > | 150000.0 | nM | - |
| CHEMBL228301 | — | IC50 | > | 150000.0 | nM | - |
| CHEMBL228360 | — | IC50 | > | 150000.0 | nM | - |
| CHEMBL228361 | — | IC50 | > | 150000.0 | nM | - |