Assay Detail
Binding
CHEMBL906836
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Inhibition of SHP-1 catalytic domain
3
Total Activities
2
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Target
Tyrosine-protein phosphatase non-receptor type 6 (CHEMBL3166) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Mono- and disalicylic acid derivatives: PTP1B inhibitors as potential anti-obesity drugs.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 4.43 | 4.43 |
| Ki | 1 | 5.01 | 5.01 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL228563 | — | — | 2 | 5.01 |
| CHEMBL390508 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL228563 | — | Ki | = | 9700.0 | nM | 5.01 |
| CHEMBL228563 | — | IC50 | = | 37000.0 | nM | 4.43 |
| CHEMBL390508 | — | IC50 | = | 129000.0 | nM | - |