Assay Detail
Binding
CHEMBL907072
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Inhibition of HDAC1 (mean IC50)
33
Total Activities
33
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
A series of novel, potent, and selective histone deacetylase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 33 | 6.83 | 9.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL216641 | — | — | 1 | 9.10 |
| CHEMBL386069 | — | — | 1 | 7.75 |
| CHEMBL384804 | — | — | 1 | 7.64 |
| CHEMBL217509 | — | — | 1 | 7.60 |
| CHEMBL98 | VORINOSTAT | 4.0 | 1 | 7.57 |
| CHEMBL217781 | — | — | 1 | 7.48 |
| CHEMBL430060 | APICIDIN | — | 1 | 7.36 |
| CHEMBL216176 | — | — | 1 | 7.36 |
| CHEMBL217651 | — | — | 1 | 7.26 |
| CHEMBL217650 | — | — | 1 | 7.26 |
| CHEMBL217314 | — | — | 1 | 7.10 |
| CHEMBL385238 | — | — | 1 | 7.00 |
| CHEMBL27759 | ENTINOSTAT | 3.0 | 1 | 6.96 |
| CHEMBL385550 | — | — | 1 | 6.82 |
| CHEMBL384993 | — | — | 1 | 6.75 |
| CHEMBL217371 | — | — | 1 | 6.72 |
| CHEMBL387224 | — | — | 1 | 6.70 |
| CHEMBL387015 | — | — | 1 | 6.66 |
| CHEMBL384384 | — | — | 1 | 6.66 |
| CHEMBL216427 | — | — | 1 | 6.64 |
| CHEMBL384463 | — | — | 1 | 6.46 |
| CHEMBL425629 | — | — | 1 | 6.32 |
| CHEMBL218129 | — | — | 1 | 6.27 |
| CHEMBL385626 | — | — | 1 | 6.25 |
| CHEMBL412598 | — | — | 1 | 6.23 |
| CHEMBL217035 | — | — | 1 | 6.23 |
| CHEMBL216336 | — | — | 1 | 6.03 |
| CHEMBL217025 | — | — | 1 | 5.75 |
| CHEMBL384472 | — | — | 1 | 5.50 |
| CHEMBL216414 | — | — | 1 | 5.48 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL216641 | — | IC50 | = | 0.8 | nM | 9.10 |
| CHEMBL386069 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL384804 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL217509 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL98 | VORINOSTAT | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL217781 | — | IC50 | = | 33.0 | nM | 7.48 |
| CHEMBL430060 | APICIDIN | IC50 | = | 44.0 | nM | 7.36 |
| CHEMBL216176 | — | IC50 | = | 44.0 | nM | 7.36 |
| CHEMBL217651 | — | IC50 | = | 55.0 | nM | 7.26 |
| CHEMBL217650 | — | IC50 | = | 55.0 | nM | 7.26 |
| CHEMBL217314 | — | IC50 | = | 79.0 | nM | 7.10 |
| CHEMBL385238 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL27759 | ENTINOSTAT | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL385550 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL384993 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL217371 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL387224 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL387015 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL384384 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL216427 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL384463 | — | IC50 | = | 350.0 | nM | 6.46 |
| CHEMBL425629 | — | IC50 | = | 480.0 | nM | 6.32 |
| CHEMBL218129 | — | IC50 | = | 540.0 | nM | 6.27 |
| CHEMBL385626 | — | IC50 | = | 560.0 | nM | 6.25 |
| CHEMBL412598 | — | IC50 | = | 590.0 | nM | 6.23 |
| CHEMBL217035 | — | IC50 | = | 590.0 | nM | 6.23 |
| CHEMBL216336 | — | IC50 | = | 930.0 | nM | 6.03 |
| CHEMBL217025 | — | IC50 | = | 1760.0 | nM | 5.75 |
| CHEMBL384472 | — | IC50 | = | 3200.0 | nM | 5.50 |
| CHEMBL216414 | — | IC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL386557 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL412599 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL386965 | — | IC50 | > | 5000.0 | nM | - |