Assay Detail
Functional
CHEMBL907122
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Cytotoxicity against human KB cell line by methylene blue dye assay
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | KB |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
7-Aroyl-aminoindoline-1-sulfonamides as a novel class of potent antitubulin agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 21 | 6.78 | 8.02 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL216327 | — | — | 1 | 8.02 |
| CHEMBL216379 | — | — | 1 | 8.02 |
| CHEMBL107 | COLCHICINE | 4.0 | 1 | 7.88 |
| CHEMBL213971 | — | — | 1 | 7.33 |
| CHEMBL386889 | — | — | 1 | 7.05 |
| CHEMBL216144 | — | — | 1 | 7.05 |
| CHEMBL385061 | — | — | 1 | 7.04 |
| CHEMBL386210 | — | — | 1 | 7.03 |
| CHEMBL217695 | — | — | 1 | 6.99 |
| CHEMBL425626 | — | — | 1 | 6.98 |
| CHEMBL216762 | — | — | 1 | 6.53 |
| CHEMBL384491 | — | — | 1 | 6.45 |
| CHEMBL217586 | — | — | 1 | 6.42 |
| CHEMBL217657 | — | — | 1 | 6.19 |
| CHEMBL217128 | — | — | 1 | 5.96 |
| CHEMBL386593 | — | — | 1 | 5.92 |
| CHEMBL217582 | — | — | 1 | 5.58 |
| CHEMBL386719 | — | — | 1 | 5.55 |
| CHEMBL268341 | — | — | 1 | - |
| CHEMBL384063 | — | — | 1 | - |
| CHEMBL215181 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL216327 | — | IC50 | = | 9.6 | nM | 8.02 |
| CHEMBL216379 | — | IC50 | = | 9.6 | nM | 8.02 |
| CHEMBL107 | COLCHICINE | IC50 | = | 13.3 | nM | 7.88 |
| CHEMBL213971 | — | IC50 | = | 47.0 | nM | 7.33 |
| CHEMBL386889 | — | IC50 | = | 89.0 | nM | 7.05 |
| CHEMBL216144 | — | IC50 | = | 89.0 | nM | 7.05 |
| CHEMBL385061 | — | IC50 | = | 91.0 | nM | 7.04 |
| CHEMBL386210 | — | IC50 | = | 93.0 | nM | 7.03 |
| CHEMBL217695 | — | IC50 | = | 102.0 | nM | 6.99 |
| CHEMBL425626 | — | IC50 | = | 105.0 | nM | 6.98 |
| CHEMBL216762 | — | IC50 | = | 297.0 | nM | 6.53 |
| CHEMBL384491 | — | IC50 | = | 359.0 | nM | 6.45 |
| CHEMBL217586 | — | IC50 | = | 376.0 | nM | 6.42 |
| CHEMBL217657 | — | IC50 | = | 650.0 | nM | 6.19 |
| CHEMBL217128 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL386593 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL217582 | — | IC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL386719 | — | IC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL268341 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL384063 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL215181 | — | IC50 | > | 10000.0 | nM | - |