Assay Detail
Functional
CHEMBL907124
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Cytotoxicity against human HT29 cell line by methylene blue dye assay
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HT-29 |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
7-Aroyl-aminoindoline-1-sulfonamides as a novel class of potent antitubulin agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 7.43 | 8.07 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL216379 | — | — | 1 | 8.07 |
| CHEMBL216327 | — | — | 1 | 8.02 |
| CHEMBL213971 | — | — | 1 | 7.43 |
| CHEMBL216144 | — | — | 1 | 7.29 |
| CHEMBL386210 | — | — | 1 | 7.26 |
| CHEMBL217695 | — | — | 1 | 7.19 |
| CHEMBL216762 | — | — | 1 | 6.72 |
| CHEMBL215181 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL216379 | — | IC50 | = | 8.6 | nM | 8.07 |
| CHEMBL216327 | — | IC50 | = | 9.5 | nM | 8.02 |
| CHEMBL213971 | — | IC50 | = | 37.0 | nM | 7.43 |
| CHEMBL216144 | — | IC50 | = | 51.0 | nM | 7.29 |
| CHEMBL386210 | — | IC50 | = | 55.0 | nM | 7.26 |
| CHEMBL217695 | — | IC50 | = | 65.0 | nM | 7.19 |
| CHEMBL216762 | — | IC50 | = | 192.0 | nM | 6.72 |
| CHEMBL215181 | — | IC50 | > | 10000.0 | nM | - |