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Assay Detail

CHEMBL907126

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Cytotoxicity against KB-VIN 10 cell line by methylene blue dye assay
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type KB
Confidence 1 — Organism
Curated By Expert

Target

KB (CHEMBL398)
Type CELL-LINE
Organism Homo sapiens

Publication

7-Aroyl-aminoindoline-1-sulfonamides as a novel class of potent antitubulin agents.
Chang JY, Hsieh HP, Chang CY, Hsu KS, Chiang YF, Chen CM, Kuo CC, Liou JP.
J Med Chem (2006) 49 : 6656 -6659
PubMed 17154496 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 9 7.29 8.05

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL216379 1 8.05
CHEMBL216327 1 8.04
CHEMBL213971 1 7.37
CHEMBL386210 1 7.07
CHEMBL216144 1 7.05
CHEMBL217695 1 7.02
CHEMBL107 COLCHICINE 4.0 1 6.93
CHEMBL216762 1 6.75
CHEMBL215181 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL216379 IC50 = 8.9 nM 8.05
CHEMBL216327 IC50 = 9.2 nM 8.04
CHEMBL213971 IC50 = 43.0 nM 7.37
CHEMBL386210 IC50 = 85.0 nM 7.07
CHEMBL216144 IC50 = 90.0 nM 7.05
CHEMBL217695 IC50 = 95.0 nM 7.02
CHEMBL107 COLCHICINE IC50 = 117.0 nM 6.93
CHEMBL216762 IC50 = 180.0 nM 6.75
CHEMBL215181 IC50 > 10000.0 nM -