Assay Detail
Binding
CHEMBL907134
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Inhibition of human cloned CA2 by CO2 hydration method
36
Total Activities
36
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
A novel class of carbonic anhydrase inhibitors: glycoconjugate benzene sulfonamides prepared by "click-tailing".
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 36 | 7.51 | 8.24 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL216319 | — | — | 1 | 8.24 |
| CHEMBL216208 | — | — | 1 | 8.17 |
| CHEMBL425274 | — | — | 1 | 8.15 |
| CHEMBL216214 | — | — | 1 | 8.15 |
| CHEMBL217288 | — | — | 1 | 8.14 |
| CHEMBL217303 | — | — | 1 | 8.14 |
| CHEMBL216312 | — | — | 1 | 8.14 |
| CHEMBL217359 | — | — | 1 | 8.14 |
| CHEMBL386416 | — | — | 1 | 8.13 |
| CHEMBL215105 | — | — | 1 | 8.12 |
| CHEMBL216563 | — | — | 1 | 8.12 |
| CHEMBL18 | ETHOXZOLAMIDE | 4.0 | 1 | 8.10 |
| CHEMBL385152 | — | — | 1 | 8.09 |
| CHEMBL214926 | — | — | 1 | 8.09 |
| CHEMBL216245 | — | — | 1 | 8.07 |
| CHEMBL220491 | BRINZOLAMIDE | 4.0 | 1 | 8.05 |
| CHEMBL20 | ACETAZOLAMIDE | 4.0 | 1 | 7.92 |
| CHEMBL19 | METHAZOLAMIDE | 4.0 | 1 | 7.85 |
| CHEMBL77517 | INDISULAM | 2.0 | 1 | 7.82 |
| CHEMBL17 | DICHLORPHENAMIDE | 4.0 | 1 | 7.42 |
| CHEMBL217304 | — | — | 1 | 7.36 |
| CHEMBL217569 | — | — | 1 | 7.35 |
| CHEMBL216210 | — | — | 1 | 7.35 |
| CHEMBL386542 | — | — | 1 | 7.33 |
| CHEMBL217454 | — | — | 1 | 7.30 |
| CHEMBL410510 | — | — | 1 | 7.05 |
| CHEMBL383897 | — | — | 1 | 6.92 |
| CHEMBL217166 | — | — | 1 | 6.89 |
| CHEMBL215182 | — | — | 1 | 6.66 |
| CHEMBL217232 | — | — | 1 | 6.58 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL216319 | — | Ki | = | 5.8 | nM | 8.24 |
| CHEMBL216208 | — | Ki | = | 6.8 | nM | 8.17 |
| CHEMBL216214 | — | Ki | = | 7.0 | nM | 8.15 |
| CHEMBL425274 | — | Ki | = | 7.0 | nM | 8.15 |
| CHEMBL217288 | — | Ki | = | 7.3 | nM | 8.14 |
| CHEMBL217303 | — | Ki | = | 7.3 | nM | 8.14 |
| CHEMBL216312 | — | Ki | = | 7.2 | nM | 8.14 |
| CHEMBL217359 | — | Ki | = | 7.3 | nM | 8.14 |
| CHEMBL386416 | — | Ki | = | 7.4 | nM | 8.13 |
| CHEMBL216563 | — | Ki | = | 7.6 | nM | 8.12 |
| CHEMBL215105 | — | Ki | = | 7.5 | nM | 8.12 |
| CHEMBL18 | ETHOXZOLAMIDE | Ki | = | 8.0 | nM | 8.10 |
| CHEMBL385152 | — | Ki | = | 8.2 | nM | 8.09 |
| CHEMBL214926 | — | Ki | = | 8.1 | nM | 8.09 |
| CHEMBL216245 | — | Ki | = | 8.6 | nM | 8.07 |
| CHEMBL220491 | BRINZOLAMIDE | Ki | = | 9.0 | nM | 8.05 |
| CHEMBL20 | ACETAZOLAMIDE | Ki | = | 12.0 | nM | 7.92 |
| CHEMBL19 | METHAZOLAMIDE | Ki | = | 14.0 | nM | 7.85 |
| CHEMBL77517 | INDISULAM | Ki | = | 15.0 | nM | 7.82 |
| CHEMBL17 | DICHLORPHENAMIDE | Ki | = | 38.0 | nM | 7.42 |
| CHEMBL217304 | — | Ki | = | 44.0 | nM | 7.36 |
| CHEMBL217569 | — | Ki | = | 45.0 | nM | 7.35 |
| CHEMBL216210 | — | Ki | = | 45.0 | nM | 7.35 |
| CHEMBL386542 | — | Ki | = | 47.0 | nM | 7.33 |
| CHEMBL217454 | — | Ki | = | 50.0 | nM | 7.30 |
| CHEMBL410510 | — | Ki | = | 90.0 | nM | 7.05 |
| CHEMBL383897 | — | Ki | = | 119.0 | nM | 6.92 |
| CHEMBL217166 | — | Ki | = | 128.0 | nM | 6.89 |
| CHEMBL215182 | — | Ki | = | 218.0 | nM | 6.66 |
| CHEMBL217232 | — | Ki | = | 265.0 | nM | 6.58 |
| CHEMBL384644 | — | Ki | = | 267.0 | nM | 6.57 |
| CHEMBL386318 | — | Ki | = | 279.0 | nM | 6.55 |
| CHEMBL217683 | — | Ki | = | 378.0 | nM | 6.42 |
| CHEMBL387076 | — | Ki | = | 384.0 | nM | 6.42 |
| CHEMBL215156 | — | Ki | = | 423.0 | nM | 6.37 |
| CHEMBL386266 | — | Ki | = | 470.0 | nM | 6.33 |