Assay Detail
Functional
CHEMBL907191
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Activity at human recombinant kappa opioid receptor expressed in CHO cells assessed as stimulation of [35S]GTP-gamma-S binding
23
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Structural determinants of opioid activity in derivatives of 14-aminomorphinones: effects of changes to the chain linking of the C14-amino group to the aryl ring.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 23 | 8.09 | 10.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL386492 | CLOCINNAMOX | — | 1 | 10.00 |
| CHEMBL217395 | — | — | 1 | 9.54 |
| CHEMBL217658 | — | — | 1 | 9.47 |
| CHEMBL217102 | — | — | 1 | 9.36 |
| CHEMBL217479 | — | — | 1 | 9.23 |
| CHEMBL448428 | — | — | 1 | 8.95 |
| CHEMBL19019 | NALTREXONE | 4.0 | 1 | 8.73 |
| CHEMBL384497 | — | — | 1 | 8.73 |
| CHEMBL216558 | — | — | 1 | 8.46 |
| CHEMBL277530 | — | — | 1 | 8.04 |
| CHEMBL386272 | — | — | 1 | 8.01 |
| CHEMBL217710 | — | — | 1 | 7.86 |
| CHEMBL383896 | — | — | 1 | 7.78 |
| CHEMBL263482 | — | — | 1 | 7.70 |
| CHEMBL217790 | — | — | 1 | 7.58 |
| CHEMBL387101 | — | — | 1 | 7.36 |
| CHEMBL216365 | — | — | 1 | 6.97 |
| CHEMBL215926 | — | — | 1 | 6.70 |
| CHEMBL411089 | — | — | 1 | 6.68 |
| CHEMBL384118 | — | — | 1 | 6.41 |
| CHEMBL387016 | — | — | 1 | 6.39 |
| CHEMBL267027 | — | — | 1 | - |
| CHEMBL443311 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL386492 | CLOCINNAMOX | IC50 | = | 0.1 | nM | 10.00 |
| CHEMBL217395 | — | IC50 | = | 0.29 | nM | 9.54 |
| CHEMBL217658 | — | IC50 | = | 0.34 | nM | 9.47 |
| CHEMBL217102 | — | IC50 | = | 0.44 | nM | 9.36 |
| CHEMBL217479 | — | IC50 | = | 0.59 | nM | 9.23 |
| CHEMBL448428 | — | IC50 | = | 1.12 | nM | 8.95 |
| CHEMBL19019 | NALTREXONE | IC50 | = | 1.86 | nM | 8.73 |
| CHEMBL384497 | — | IC50 | = | 1.87 | nM | 8.73 |
| CHEMBL216558 | — | IC50 | = | 3.45 | nM | 8.46 |
| CHEMBL277530 | — | IC50 | = | 9.07 | nM | 8.04 |
| CHEMBL386272 | — | IC50 | = | 9.81 | nM | 8.01 |
| CHEMBL217710 | — | IC50 | = | 13.8 | nM | 7.86 |
| CHEMBL383896 | — | IC50 | = | 16.7 | nM | 7.78 |
| CHEMBL263482 | — | IC50 | = | 20.2 | nM | 7.70 |
| CHEMBL217790 | — | IC50 | = | 26.2 | nM | 7.58 |
| CHEMBL387101 | — | IC50 | = | 43.4 | nM | 7.36 |
| CHEMBL216365 | — | IC50 | = | 106.0 | nM | 6.97 |
| CHEMBL215926 | — | IC50 | = | 202.0 | nM | 6.70 |
| CHEMBL411089 | — | IC50 | = | 208.0 | nM | 6.68 |
| CHEMBL384118 | — | IC50 | = | 387.0 | nM | 6.41 |
| CHEMBL387016 | — | IC50 | = | 410.0 | nM | 6.39 |
| CHEMBL267027 | — | IC50 | = | 0.003 | nM | - |
| CHEMBL443311 | — | IC50 | = | 0.006 | nM | - |