Assay Detail
Binding
CHEMBL907248
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Inhibition of HCV NS5B RNA polymerase
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Hepacivirus hominis |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
RNA-directed RNA polymerase (CHEMBL4296320) ↗| Type | SINGLE PROTEIN |
| Organism | Hepacivirus hominis |
Publication
Discovery of conformationally constrained tetracyclic compounds as potent hepatitis C virus NS5B RNA polymerase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 20 | 7.29 | 8.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1203926 | — | — | 1 | 8.05 |
| CHEMBL386319 | — | — | 1 | 7.77 |
| CHEMBL1204385 | — | — | 1 | 7.75 |
| CHEMBL215056 | — | — | 1 | 7.72 |
| CHEMBL1203925 | — | — | 1 | 7.68 |
| CHEMBL385407 | — | — | 1 | 7.62 |
| CHEMBL216865 | — | — | 1 | 7.58 |
| CHEMBL386726 | — | — | 1 | 7.58 |
| CHEMBL216143 | — | — | 1 | 7.44 |
| CHEMBL215708 | — | — | 1 | 7.42 |
| CHEMBL440992 | — | — | 1 | 7.39 |
| CHEMBL216647 | — | — | 1 | 7.34 |
| CHEMBL217259 | — | — | 1 | 7.33 |
| CHEMBL216384 | — | — | 1 | 7.11 |
| CHEMBL217670 | — | — | 1 | 6.92 |
| CHEMBL217213 | — | — | 1 | 6.92 |
| CHEMBL425286 | — | — | 1 | 6.85 |
| CHEMBL385206 | — | — | 1 | 6.85 |
| CHEMBL217807 | — | — | 1 | 6.68 |
| CHEMBL379677 | — | — | 1 | 5.85 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1203926 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL386319 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL1204385 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL215056 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL1203925 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL385407 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL216865 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL386726 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL216143 | — | IC50 | = | 36.0 | nM | 7.44 |
| CHEMBL215708 | — | IC50 | = | 38.0 | nM | 7.42 |
| CHEMBL440992 | — | IC50 | = | 41.0 | nM | 7.39 |
| CHEMBL216647 | — | IC50 | = | 46.0 | nM | 7.34 |
| CHEMBL217259 | — | IC50 | = | 47.0 | nM | 7.33 |
| CHEMBL216384 | — | IC50 | = | 77.0 | nM | 7.11 |
| CHEMBL217670 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL217213 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL425286 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL385206 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL217807 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL379677 | — | IC50 | = | 1400.0 | nM | 5.85 |