Assay Detail
Binding
CHEMBL907266
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Inhibition of human EGLN1
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Structure-based design, synthesis, and SAR evaluation of a new series of 8-hydroxyquinolines as HIF-1alpha prolyl hydroxylase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 20 | 5.23 | 5.50 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL374946 | — | — | 1 | 5.50 |
| CHEMBL221919 | — | — | 1 | 5.41 |
| CHEMBL218481 | — | — | 1 | 5.39 |
| CHEMBL217943 | — | — | 1 | 5.38 |
| CHEMBL387428 | — | — | 1 | 5.36 |
| CHEMBL217944 | — | — | 1 | 5.36 |
| CHEMBL221026 | — | — | 1 | 5.34 |
| CHEMBL221027 | — | — | 1 | 5.32 |
| CHEMBL441860 | — | — | 1 | 5.30 |
| CHEMBL221604 | — | — | 1 | 5.28 |
| CHEMBL384018 | — | — | 1 | 5.24 |
| CHEMBL218288 | — | — | 1 | 5.22 |
| CHEMBL218493 | — | — | 1 | 5.21 |
| CHEMBL220659 | — | — | 1 | 5.16 |
| CHEMBL221971 | — | — | 1 | 5.14 |
| CHEMBL218005 | — | — | 1 | 5.13 |
| CHEMBL221918 | — | — | 1 | 5.01 |
| CHEMBL218482 | — | — | 1 | 5.00 |
| CHEMBL217945 | — | — | 1 | 4.54 |
| CHEMBL374569 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL374946 | — | IC50 | = | 3200.0 | nM | 5.50 |
| CHEMBL221919 | — | IC50 | = | 3900.0 | nM | 5.41 |
| CHEMBL218481 | — | IC50 | = | 4100.0 | nM | 5.39 |
| CHEMBL217943 | — | IC50 | = | 4200.0 | nM | 5.38 |
| CHEMBL387428 | — | IC50 | = | 4400.0 | nM | 5.36 |
| CHEMBL217944 | — | IC50 | = | 4400.0 | nM | 5.36 |
| CHEMBL221026 | — | IC50 | = | 4600.0 | nM | 5.34 |
| CHEMBL221027 | — | IC50 | = | 4800.0 | nM | 5.32 |
| CHEMBL441860 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL221604 | — | IC50 | = | 5300.0 | nM | 5.28 |
| CHEMBL384018 | — | IC50 | = | 5800.0 | nM | 5.24 |
| CHEMBL218288 | — | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL218493 | — | IC50 | = | 6100.0 | nM | 5.21 |
| CHEMBL220659 | — | IC50 | = | 6900.0 | nM | 5.16 |
| CHEMBL221971 | — | IC50 | = | 7200.0 | nM | 5.14 |
| CHEMBL218005 | — | IC50 | = | 7400.0 | nM | 5.13 |
| CHEMBL221918 | — | IC50 | = | 9700.0 | nM | 5.01 |
| CHEMBL218482 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL217945 | — | IC50 | = | 28700.0 | nM | 4.54 |
| CHEMBL374569 | — | IC50 | > | 100000.0 | nM | - |