Assay Detail
Binding
CHEMBL907300
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Inhibition of integrin alphavbeta3 mediated cell adhesion of human M21 cells to vitronectin
26
Total Activities
26
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | M21 |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Discovery of small molecule inhibitors of integrin alphavbeta3 through structure-based virtual screening.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 26 | 4.50 | 6.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL411941 | CYCLORGDFV | — | 1 | 6.22 |
| CHEMBL40929 | — | — | 1 | 4.47 |
| CHEMBL41433 | — | — | 1 | 4.42 |
| CHEMBL220928 | — | — | 1 | 4.40 |
| CHEMBL221248 | — | — | 1 | 4.27 |
| CHEMBL220979 | — | — | 1 | 4.17 |
| CHEMBL185802 | — | — | 1 | 4.06 |
| CHEMBL222122 | — | — | 1 | 4.01 |
| CHEMBL13791 | PHENYL BIGUANIDE | — | 1 | - |
| CHEMBL221310 | — | — | 1 | - |
| CHEMBL42752 | — | — | 1 | - |
| CHEMBL375650 | — | — | 1 | - |
| CHEMBL221309 | — | — | 1 | - |
| CHEMBL221253 | — | — | 1 | - |
| CHEMBL375434 | — | — | 1 | - |
| CHEMBL13790 | — | — | 1 | - |
| CHEMBL221306 | — | — | 1 | - |
| CHEMBL840 | 4-CHLOROPHENYLBIGUANIDE | — | 1 | - |
| CHEMBL219484 | — | — | 1 | - |
| CHEMBL219378 | — | — | 1 | - |
| CHEMBL386940 | — | — | 1 | - |
| CHEMBL220869 | — | — | 1 | - |
| CHEMBL385111 | — | — | 1 | - |
| CHEMBL386939 | — | — | 1 | - |
| CHEMBL376494 | — | — | 1 | - |
| CHEMBL221952 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL411941 | CYCLORGDFV | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL40929 | — | IC50 | = | 33500.0 | nM | 4.47 |
| CHEMBL41433 | — | IC50 | = | 38500.0 | nM | 4.42 |
| CHEMBL220928 | — | IC50 | = | 39500.0 | nM | 4.40 |
| CHEMBL221248 | — | IC50 | = | 53500.0 | nM | 4.27 |
| CHEMBL220979 | — | IC50 | = | 66900.0 | nM | 4.17 |
| CHEMBL185802 | — | IC50 | = | 87300.0 | nM | 4.06 |
| CHEMBL222122 | — | IC50 | = | 97300.0 | nM | 4.01 |
| CHEMBL13791 | PHENYL BIGUANIDE | IC50 | > | 200000.0 | nM | - |
| CHEMBL221310 | — | IC50 | > | 200000.0 | nM | - |
| CHEMBL42752 | — | IC50 | > | 200000.0 | nM | - |
| CHEMBL375650 | — | IC50 | > | 200000.0 | nM | - |
| CHEMBL221309 | — | IC50 | > | 200000.0 | nM | - |
| CHEMBL221253 | — | IC50 | > | 200000.0 | nM | - |
| CHEMBL375434 | — | IC50 | > | 200000.0 | nM | - |
| CHEMBL13790 | — | IC50 | = | 190600.0 | nM | - |
| CHEMBL221306 | — | IC50 | = | 178100.0 | nM | - |
| CHEMBL840 | 4-CHLOROPHENYLBIGUANIDE | IC50 | = | 148600.0 | nM | - |
| CHEMBL219484 | — | IC50 | = | 127200.0 | nM | - |
| CHEMBL219378 | — | IC50 | = | 101400.0 | nM | - |
| CHEMBL386940 | — | IC50 | = | 162100.0 | nM | - |
| CHEMBL220869 | — | IC50 | = | 137000.0 | nM | - |
| CHEMBL385111 | — | IC50 | = | 132000.0 | nM | - |
| CHEMBL386939 | — | IC50 | = | 143100.0 | nM | - |
| CHEMBL376494 | — | IC50 | = | 180400.0 | nM | - |
| CHEMBL221952 | — | IC50 | = | 100200.0 | nM | - |