Assay Detail
Binding
CHEMBL907491
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Inhibition of human HDAC1 expressed in domain of SMRT
22
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Design of novel histone deacetylase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 22 | 6.93 | 8.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL250946 | — | — | 1 | 8.30 |
| CHEMBL400919 | — | — | 1 | 7.68 |
| CHEMBL251145 | — | — | 1 | 7.47 |
| CHEMBL251337 | — | — | 1 | 7.46 |
| CHEMBL251144 | — | — | 1 | 7.44 |
| CHEMBL400920 | — | — | 1 | 7.35 |
| CHEMBL398950 | — | — | 1 | 7.33 |
| CHEMBL251338 | — | — | 1 | 7.33 |
| CHEMBL251756 | — | — | 1 | 7.32 |
| CHEMBL251336 | — | — | 1 | 7.25 |
| CHEMBL251146 | — | — | 1 | 7.20 |
| CHEMBL251757 | — | — | 1 | 7.03 |
| CHEMBL400921 | — | — | 1 | 6.99 |
| CHEMBL251544 | — | — | 1 | 6.71 |
| CHEMBL398333 | — | — | 1 | 6.70 |
| CHEMBL248718 | — | — | 1 | 6.70 |
| CHEMBL248909 | — | — | 1 | 6.70 |
| CHEMBL251546 | — | — | 1 | 6.64 |
| CHEMBL249284 | — | — | 1 | 6.15 |
| CHEMBL251545 | — | — | 1 | 5.14 |
| CHEMBL16300 | BENZOHYDROXAMATE | — | 1 | 4.70 |
| CHEMBL734 | ACETOHYDROXAMIC ACID | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL250946 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL400919 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL251145 | — | IC50 | = | 34.0 | nM | 7.47 |
| CHEMBL251337 | — | IC50 | = | 35.0 | nM | 7.46 |
| CHEMBL251144 | — | IC50 | = | 36.0 | nM | 7.44 |
| CHEMBL400920 | — | IC50 | = | 45.0 | nM | 7.35 |
| CHEMBL398950 | — | IC50 | = | 47.0 | nM | 7.33 |
| CHEMBL251338 | — | IC50 | = | 47.0 | nM | 7.33 |
| CHEMBL251756 | — | IC50 | = | 48.0 | nM | 7.32 |
| CHEMBL251336 | — | IC50 | = | 56.0 | nM | 7.25 |
| CHEMBL251146 | — | IC50 | = | 63.0 | nM | 7.20 |
| CHEMBL251757 | — | IC50 | = | 94.0 | nM | 7.03 |
| CHEMBL400921 | — | IC50 | = | 103.0 | nM | 6.99 |
| CHEMBL251544 | — | IC50 | = | 196.0 | nM | 6.71 |
| CHEMBL398333 | — | IC50 | = | 199.0 | nM | 6.70 |
| CHEMBL248718 | — | IC50 | = | 198.0 | nM | 6.70 |
| CHEMBL248909 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL251546 | — | IC50 | = | 229.0 | nM | 6.64 |
| CHEMBL249284 | — | IC50 | = | 715.0 | nM | 6.15 |
| CHEMBL251545 | — | IC50 | = | 7195.0 | nM | 5.14 |
| CHEMBL16300 | BENZOHYDROXAMATE | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL734 | ACETOHYDROXAMIC ACID | IC50 | = | 625000.0 | nM | - |