Assay Detail
Binding
CHEMBL907581
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Inhibition of IKK2
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Inhibitor of nuclear factor kappa-B kinase subunit beta (CHEMBL1991) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Synthesis and biological evaluation of 4-amino derivatives of benzimidazoquinoxaline, benzimidazoquinoline, and benzopyrazoloquinazoline as potent IKK inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 7.46 | 7.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL390201 | — | — | 1 | 7.96 |
| CHEMBL230184 | — | — | 1 | 7.75 |
| CHEMBL231530 | — | — | 1 | 7.75 |
| CHEMBL536520 | — | — | 1 | 7.64 |
| CHEMBL230186 | — | — | 1 | 7.46 |
| CHEMBL230185 | — | — | 1 | 7.34 |
| CHEMBL231037 | — | — | 1 | 7.24 |
| CHEMBL471496 | — | — | 1 | 6.52 |
| CHEMBL231036 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL390201 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL230184 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL231530 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL536520 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL230186 | — | IC50 | = | 35.0 | nM | 7.46 |
| CHEMBL230185 | — | IC50 | = | 46.0 | nM | 7.34 |
| CHEMBL231037 | — | IC50 | = | 58.0 | nM | 7.24 |
| CHEMBL471496 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL231036 | — | IC50 | - | — | - |