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Assay Detail

CHEMBL907598

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Functional
Inhibition of DPPH radical scavenging activity
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Confidence 0 — Uncurated / Unknown
Curated By Autocuration

Target

Unchecked (CHEMBL612545)
Type UNCHECKED

Publication

Synthesis of O-prenylated and O-geranylated derivatives of 5-benzylidene2,4-thiazolidinediones and evaluation of their free radical scavenging activity as well as effect on some phase II antioxidant/detoxifying enzymes.
Hossain SU, Bhattacharya S.
Bioorg Med Chem Lett (2007) 17 : 1149 -1154
PubMed 17197183 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 13 5.00 5.64

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL47 ALPHA-TOCOPHEROL 1 5.64
CHEMBL231354 1 5.60
CHEMBL231450 1 5.54
CHEMBL231452 1 5.39
CHEMBL388493 1 5.01
CHEMBL231453 1 4.92
CHEMBL231516 1 4.92
CHEMBL390890 1 4.75
CHEMBL388492 1 4.75
CHEMBL396959 1 4.63
CHEMBL229991 1 4.49
CHEMBL231451 1 4.36
CHEMBL389775 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL47 ALPHA-TOCOPHEROL IC50 = 2300.0 nM 5.64
CHEMBL231354 IC50 = 2490.0 nM 5.60
CHEMBL231450 IC50 = 2850.0 nM 5.54
CHEMBL231452 IC50 = 4080.0 nM 5.39
CHEMBL388493 IC50 = 9800.0 nM 5.01
CHEMBL231453 IC50 = 11970.0 nM 4.92
CHEMBL231516 IC50 = 11970.0 nM 4.92
CHEMBL390890 IC50 = 17570.0 nM 4.75
CHEMBL388492 IC50 = 17890.0 nM 4.75
CHEMBL396959 IC50 = 23490.0 nM 4.63
CHEMBL229991 IC50 = 32130.0 nM 4.49
CHEMBL231451 IC50 = 43300.0 nM 4.36
CHEMBL389775 IC50 > 50000.0 nM -