Assay Detail
Functional
CHEMBL907640
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Anticoagulant activity in human plasma
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Tissue | Plasma |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design, synthesis, and biological evaluation of peptidomimetic inhibitors of factor XIa as novel anticoagulants.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 7.95 | 8.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL413155 | — | — | 1 | 8.22 |
| CHEMBL265121 | — | — | 1 | 8.10 |
| CHEMBL375816 | — | — | 1 | 8.00 |
| CHEMBL264357 | — | — | 1 | 7.92 |
| CHEMBL273653 | — | — | 1 | 7.52 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL413155 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL265121 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL375816 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL264357 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL273653 | — | IC50 | = | 30.0 | nM | 7.52 |