Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL907758

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Displacement of [3H]T-0901317 from human LXR beta receptor
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Expert

Target

Oxysterols receptor LXR-beta (CHEMBL4093)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Discovery of phenyl acetic acid substituted quinolines as novel liver X receptor agonists for the treatment of atherosclerosis.
Hu B, Collini M, Unwalla R, Miller C, Singhaus R, Quinet E, Savio D, Halpern A, Basso M, Keith J, Clerin V, Chen L, Resmini C, Liu QY, Feingold I, Huselton C, Azam F, Farnegardh M, Enroth C, Bonn T, Goos-Nilsson A, Wilhelmsson A, Nambi P, Wrobel J.
J Med Chem (2006) 49 : 6151 -6154
PubMed 17034119 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 12 7.49 8.72

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL217118 1 8.72
CHEMBL214719 1 8.68
CHEMBL386772 1 8.30
CHEMBL216645 1 8.15
CHEMBL62136 T091317 1 8.00
CHEMBL59030 1 7.92
CHEMBL214074 1 7.17
CHEMBL425099 1 6.97
CHEMBL214324 1 6.94
CHEMBL217376 1 5.99
CHEMBL214465 1 5.56
CHEMBL217704 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL217118 IC50 = 1.9 nM 8.72
CHEMBL214719 IC50 = 2.1 nM 8.68
CHEMBL386772 IC50 = 5.0 nM 8.30
CHEMBL216645 IC50 = 7.0 nM 8.15
CHEMBL62136 T091317 IC50 = 10.0 nM 8.00
CHEMBL59030 IC50 = 12.0 nM 7.92
CHEMBL214074 IC50 = 67.0 nM 7.17
CHEMBL425099 IC50 = 107.0 nM 6.97
CHEMBL214324 IC50 = 115.0 nM 6.94
CHEMBL217376 IC50 = 1033.0 nM 5.99
CHEMBL214465 IC50 = 2738.0 nM 5.56
CHEMBL217704 IC50 > 1000.0 nM -