Assay Detail
Functional
CHEMBL907771
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at human LXR beta receptor expressed in CHO cells by reporter assay
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Discovery of phenyl acetic acid substituted quinolines as novel liver X receptor agonists for the treatment of atherosclerosis.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 12 | 6.62 | 7.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL62136 | T091317 | — | 1 | 7.80 |
| CHEMBL217118 | — | — | 1 | 7.48 |
| CHEMBL214719 | — | — | 1 | 7.15 |
| CHEMBL386772 | — | — | 1 | 6.84 |
| CHEMBL214074 | — | — | 1 | 6.73 |
| CHEMBL217704 | — | — | 1 | 6.53 |
| CHEMBL214324 | — | — | 1 | 6.43 |
| CHEMBL59030 | — | — | 1 | 6.39 |
| CHEMBL425099 | — | — | 1 | 5.85 |
| CHEMBL214465 | — | — | 1 | 5.82 |
| CHEMBL217376 | — | — | 1 | 5.82 |
| CHEMBL216645 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL62136 | T091317 | EC50 | = | 16.0 | nM | 7.80 |
| CHEMBL217118 | — | EC50 | = | 33.0 | nM | 7.48 |
| CHEMBL214719 | — | EC50 | = | 71.0 | nM | 7.15 |
| CHEMBL386772 | — | EC50 | = | 143.0 | nM | 6.84 |
| CHEMBL214074 | — | EC50 | = | 186.0 | nM | 6.73 |
| CHEMBL217704 | — | EC50 | = | 296.0 | nM | 6.53 |
| CHEMBL214324 | — | EC50 | = | 374.0 | nM | 6.43 |
| CHEMBL59030 | — | EC50 | = | 410.0 | nM | 6.39 |
| CHEMBL425099 | — | EC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL214465 | — | EC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL217376 | — | EC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL216645 | — | EC50 | - | — | - |