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Assay Detail

CHEMBL907787

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Displacement of [3H]Cl-DPDPE from human recombinant delta opioid receptor expressed in CHO cells
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Cell Type CHO
Confidence 9 — Direct single protein target
Curated By Expert

Target

Delta-type opioid receptor (CHEMBL236)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Structural determinants of opioid activity in derivatives of 14-aminomorphinones: effects of changes to the chain linking of the C14-amino group to the aryl ring.
Rennison D, Moynihan H, Traynor JR, Lewis JW, Husbands SM.
J Med Chem (2006) 49 : 6104 -6110
PubMed 17004724 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 19 7.83 8.82

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL448428 1 8.82
CHEMBL217658 1 8.72
CHEMBL383896 1 8.68
CHEMBL217102 1 8.66
CHEMBL386492 CLOCINNAMOX 1 8.57
CHEMBL217710 1 8.49
CHEMBL217479 1 8.41
CHEMBL386272 1 8.32
CHEMBL216558 1 8.18
CHEMBL19019 NALTREXONE 4.0 1 7.97
CHEMBL411089 1 7.61
CHEMBL387101 1 7.47
CHEMBL277530 1 7.29
CHEMBL215926 1 7.25
CHEMBL263482 1 7.05
CHEMBL384118 1 7.02
CHEMBL216365 1 6.98
CHEMBL217790 1 6.62
CHEMBL387016 1 6.57

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL448428 Ki = 1.51 nM 8.82
CHEMBL217658 Ki = 1.91 nM 8.72
CHEMBL383896 Ki = 2.1 nM 8.68
CHEMBL217102 Ki = 2.18 nM 8.66
CHEMBL386492 CLOCINNAMOX Ki = 2.69 nM 8.57
CHEMBL217710 Ki = 3.25 nM 8.49
CHEMBL217479 Ki = 3.85 nM 8.41
CHEMBL386272 Ki = 4.79 nM 8.32
CHEMBL216558 Ki = 6.65 nM 8.18
CHEMBL19019 NALTREXONE Ki = 10.8 nM 7.97
CHEMBL411089 Ki = 24.8 nM 7.61
CHEMBL387101 Ki = 33.8 nM 7.47
CHEMBL277530 Ki = 51.9 nM 7.29
CHEMBL215926 Ki = 55.9 nM 7.25
CHEMBL263482 Ki = 89.4 nM 7.05
CHEMBL384118 Ki = 94.9 nM 7.02
CHEMBL216365 Ki = 104.0 nM 6.98
CHEMBL217790 Ki = 242.0 nM 6.62
CHEMBL387016 Ki = 272.0 nM 6.57