Assay Detail
Binding
CHEMBL907874
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Inhibition of VEGFR2
25
Total Activities
25
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Vascular endothelial growth factor receptor 2 (CHEMBL279) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Synthesis and biological study of 4-aminopyrimidine-5-carboxaldehyde oximes as antiproliferative VEGFR-2 inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 25 | 6.92 | 7.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL222076 | — | — | 1 | 7.96 |
| CHEMBL219983 | — | — | 1 | 7.62 |
| CHEMBL220988 | — | — | 1 | 7.48 |
| CHEMBL220391 | — | — | 1 | 7.41 |
| CHEMBL223892 | — | — | 1 | 7.38 |
| CHEMBL426929 | — | — | 1 | 7.37 |
| CHEMBL220890 | — | — | 1 | 7.36 |
| CHEMBL221224 | — | — | 1 | 7.28 |
| CHEMBL219676 | — | — | 1 | 7.28 |
| CHEMBL220951 | — | — | 1 | 7.21 |
| CHEMBL223535 | — | — | 1 | 7.03 |
| CHEMBL220444 | — | — | 1 | 7.00 |
| CHEMBL373826 | — | — | 1 | 6.94 |
| CHEMBL374240 | — | — | 1 | 6.93 |
| CHEMBL223622 | — | — | 1 | 6.92 |
| CHEMBL223486 | — | — | 1 | 6.84 |
| CHEMBL222828 | — | — | 1 | 6.73 |
| CHEMBL435748 | — | — | 1 | 6.70 |
| CHEMBL223086 | — | — | 1 | 6.67 |
| CHEMBL387313 | — | — | 1 | 6.56 |
| CHEMBL219677 | — | — | 1 | 6.38 |
| CHEMBL220523 | — | — | 1 | 6.16 |
| CHEMBL223534 | — | — | 1 | 5.98 |
| CHEMBL219729 | — | — | 1 | 5.92 |
| CHEMBL219886 | — | — | 1 | 5.80 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL222076 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL219983 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL220988 | — | IC50 | = | 33.0 | nM | 7.48 |
| CHEMBL220391 | — | IC50 | = | 39.0 | nM | 7.41 |
| CHEMBL223892 | — | IC50 | = | 42.0 | nM | 7.38 |
| CHEMBL426929 | — | IC50 | = | 43.0 | nM | 7.37 |
| CHEMBL220890 | — | IC50 | = | 44.0 | nM | 7.36 |
| CHEMBL221224 | — | IC50 | = | 52.0 | nM | 7.28 |
| CHEMBL219676 | — | IC50 | = | 52.0 | nM | 7.28 |
| CHEMBL220951 | — | IC50 | = | 62.0 | nM | 7.21 |
| CHEMBL223535 | — | IC50 | = | 93.0 | nM | 7.03 |
| CHEMBL220444 | — | IC50 | = | 101.0 | nM | 7.00 |
| CHEMBL373826 | — | IC50 | = | 115.0 | nM | 6.94 |
| CHEMBL374240 | — | IC50 | = | 117.0 | nM | 6.93 |
| CHEMBL223622 | — | IC50 | = | 121.0 | nM | 6.92 |
| CHEMBL223486 | — | IC50 | = | 146.0 | nM | 6.84 |
| CHEMBL222828 | — | IC50 | = | 187.0 | nM | 6.73 |
| CHEMBL435748 | — | IC50 | = | 201.0 | nM | 6.70 |
| CHEMBL223086 | — | IC50 | = | 214.0 | nM | 6.67 |
| CHEMBL387313 | — | IC50 | = | 276.0 | nM | 6.56 |
| CHEMBL219677 | — | IC50 | = | 413.0 | nM | 6.38 |
| CHEMBL220523 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL223534 | — | IC50 | = | 1038.0 | nM | 5.98 |
| CHEMBL219729 | — | IC50 | = | 1189.0 | nM | 5.92 |
| CHEMBL219886 | — | IC50 | = | 1588.0 | nM | 5.80 |