Assay Detail
Functional
CHEMBL907939
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Activity at human DP receptor in washed platelets assessed as inhibition of PGD2-induced cAMP accumulation
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Discovery of a potent and selective prostaglandin D2 receptor antagonist, [(3R)-4-(4-chloro-benzyl)-7-fluoro-5-(methylsulfonyl)-1,2,3,4-tetrahydrocyclopenta[b]indol-3-yl]-acetic acid (MK-0524).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 9.32 | 10.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL426559 | LAROPIPRANT | 4.0 | 1 | 10.05 |
| CHEMBL426387 | — | — | 1 | 9.59 |
| CHEMBL385126 | — | — | 1 | 9.54 |
| CHEMBL383484 | — | — | 1 | 8.70 |
| CHEMBL207203 | — | — | 1 | 8.70 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL426559 | LAROPIPRANT | IC50 | = | 0.09 | nM | 10.05 |
| CHEMBL426387 | — | IC50 | = | 0.26 | nM | 9.59 |
| CHEMBL385126 | — | IC50 | = | 0.29 | nM | 9.54 |
| CHEMBL383484 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL207203 | — | IC50 | = | 2.0 | nM | 8.70 |