Assay Detail
Functional
CHEMBL908008
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against human HeLa cell line assessed as incorporation [14C]thymidine
23
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HeLa |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Synthesis of 2-amino-4-(7-azaindol-3-yl)pyrimidines as cyclin dependent kinase 1 (CDK1) inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 23 | 6.97 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL212299 | — | — | 1 | 9.00 |
| CHEMBL384350 | — | — | 1 | 8.52 |
| CHEMBL212552 | — | — | 1 | 8.52 |
| CHEMBL377449 | — | — | 1 | 8.52 |
| CHEMBL426509 | — | — | 1 | 7.96 |
| CHEMBL385275 | — | — | 1 | 7.64 |
| CHEMBL212491 | — | — | 1 | 7.55 |
| CHEMBL385478 | — | — | 1 | 7.51 |
| CHEMBL377048 | — | — | 1 | 7.04 |
| CHEMBL380301 | — | — | 1 | 7.02 |
| CHEMBL212908 | — | — | 1 | 6.89 |
| CHEMBL212833 | — | — | 1 | 6.85 |
| CHEMBL383893 | — | — | 1 | 6.66 |
| CHEMBL213277 | — | — | 1 | 6.54 |
| CHEMBL214819 | — | — | 1 | 6.54 |
| CHEMBL213023 | — | — | 1 | 6.46 |
| CHEMBL213207 | — | — | 1 | 6.43 |
| CHEMBL378768 | — | — | 1 | 6.42 |
| CHEMBL385827 | — | — | 1 | 6.41 |
| CHEMBL215048 | — | — | 1 | 6.41 |
| CHEMBL213204 | — | — | 1 | 6.02 |
| CHEMBL212347 | — | — | 1 | 5.05 |
| CHEMBL214055 | — | — | 1 | 4.28 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL212299 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL384350 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL212552 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL377449 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL426509 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL385275 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL212491 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL385478 | — | IC50 | = | 31.0 | nM | 7.51 |
| CHEMBL377048 | — | IC50 | = | 92.0 | nM | 7.04 |
| CHEMBL380301 | — | IC50 | = | 95.0 | nM | 7.02 |
| CHEMBL212908 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL212833 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL383893 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL213277 | — | IC50 | = | 292.0 | nM | 6.54 |
| CHEMBL214819 | — | IC50 | = | 290.0 | nM | 6.54 |
| CHEMBL213023 | — | IC50 | = | 350.0 | nM | 6.46 |
| CHEMBL213207 | — | IC50 | = | 368.0 | nM | 6.43 |
| CHEMBL378768 | — | IC50 | = | 382.0 | nM | 6.42 |
| CHEMBL385827 | — | IC50 | = | 392.0 | nM | 6.41 |
| CHEMBL215048 | — | IC50 | = | 393.0 | nM | 6.41 |
| CHEMBL213204 | — | IC50 | = | 955.0 | nM | 6.02 |
| CHEMBL212347 | — | IC50 | = | 8900.0 | nM | 5.05 |
| CHEMBL214055 | — | IC50 | = | 52100.0 | nM | 4.28 |