Assay Detail
Binding
CHEMBL908009
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human uPA
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Urokinase-type plasminogen activator (CHEMBL3286) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Diphenyl phosphonate inhibitors for the urokinase-type plasminogen activator: optimization of the P4 position.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 17 | 8.24 | 8.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL385900 | — | — | 1 | 8.82 |
| CHEMBL385158 | — | — | 1 | 8.59 |
| CHEMBL214814 | — | — | 1 | 8.46 |
| CHEMBL80844 | — | — | 1 | 8.37 |
| CHEMBL384263 | — | — | 1 | 8.36 |
| CHEMBL405546 | — | — | 1 | 8.30 |
| CHEMBL263977 | — | — | 1 | 8.30 |
| CHEMBL385897 | — | — | 1 | 8.24 |
| CHEMBL386275 | — | — | 1 | 8.24 |
| CHEMBL189823 | — | — | 1 | 8.22 |
| CHEMBL215961 | — | — | 1 | 8.21 |
| CHEMBL386249 | — | — | 1 | 8.18 |
| CHEMBL214539 | — | — | 1 | 8.17 |
| CHEMBL213216 | — | — | 1 | 8.16 |
| CHEMBL404226 | — | — | 1 | 8.15 |
| CHEMBL411215 | — | — | 1 | 8.10 |
| CHEMBL311067 | — | — | 1 | 7.21 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL385900 | — | IC50 | = | 1.5 | nM | 8.82 |
| CHEMBL385158 | — | IC50 | = | 2.6 | nM | 8.59 |
| CHEMBL214814 | — | IC50 | = | 3.5 | nM | 8.46 |
| CHEMBL80844 | — | IC50 | = | 4.3 | nM | 8.37 |
| CHEMBL384263 | — | IC50 | = | 4.4 | nM | 8.36 |
| CHEMBL405546 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL263977 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL385897 | — | IC50 | = | 5.8 | nM | 8.24 |
| CHEMBL386275 | — | IC50 | = | 5.8 | nM | 8.24 |
| CHEMBL189823 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL215961 | — | IC50 | = | 6.2 | nM | 8.21 |
| CHEMBL386249 | — | IC50 | = | 6.6 | nM | 8.18 |
| CHEMBL214539 | — | IC50 | = | 6.7 | nM | 8.17 |
| CHEMBL213216 | — | IC50 | = | 6.9 | nM | 8.16 |
| CHEMBL404226 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL411215 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL311067 | — | IC50 | = | 61.0 | nM | 7.21 |