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Assay Detail

CHEMBL908010

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of human plasmin
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Expert

Target

Plasminogen (CHEMBL1801)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Diphenyl phosphonate inhibitors for the urokinase-type plasminogen activator: optimization of the P4 position.
Joossens J, Van der Veken P, Surpateanu G, Lambeir AM, El-Sayed I, Ali OM, Augustyns K, Haemers A.
J Med Chem (2006) 49 : 5785 -5793
PubMed 16970403 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 17 5.62 7.43

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL214814 1 7.43
CHEMBL215961 1 6.05
CHEMBL386249 1 6.05
CHEMBL214539 1 6.05
CHEMBL385897 1 6.00
CHEMBL385900 1 5.81
CHEMBL386275 1 5.77
CHEMBL385158 1 5.72
CHEMBL80844 1 5.70
CHEMBL189823 1 5.38
CHEMBL404226 1 5.30
CHEMBL411215 1 5.30
CHEMBL405546 1 5.14
CHEMBL384263 1 5.10
CHEMBL213216 1 5.00
CHEMBL311067 1 4.97
CHEMBL263977 1 4.82

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL214814 IC50 = 37.0 nM 7.43
CHEMBL215961 IC50 = 900.0 nM 6.05
CHEMBL386249 IC50 = 900.0 nM 6.05
CHEMBL214539 IC50 = 900.0 nM 6.05
CHEMBL385897 IC50 = 990.0 nM 6.00
CHEMBL385900 IC50 = 1540.0 nM 5.81
CHEMBL386275 IC50 = 1700.0 nM 5.77
CHEMBL385158 IC50 = 1900.0 nM 5.72
CHEMBL80844 IC50 = 2000.0 nM 5.70
CHEMBL189823 IC50 = 4200.0 nM 5.38
CHEMBL404226 IC50 = 5000.0 nM 5.30
CHEMBL411215 IC50 = 5000.0 nM 5.30
CHEMBL405546 IC50 = 7200.0 nM 5.14
CHEMBL384263 IC50 = 8000.0 nM 5.10
CHEMBL213216 IC50 = 10000.0 nM 5.00
CHEMBL311067 IC50 = 10800.0 nM 4.97
CHEMBL263977 IC50 = 15000.0 nM 4.82