Assay Detail
Binding
CHEMBL908048
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of cy3B-GM from Hsp90alpha
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Synthesis of a red-shifted fluorescence polarization probe for Hsp90.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 4 | 6.78 | 7.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL200102 | PU-H71 | 2.0 | 1 | 7.22 |
| CHEMBL109480 | TANESPIMYCIN | 3.0 | 1 | 7.19 |
| CHEMBL112953 | — | — | 1 | 5.92 |
| CHEMBL14830 | ADENOSINE DIPHOSPHATE | 0.5 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL200102 | PU-H71 | EC50 | = | 59.6 | nM | 7.22 |
| CHEMBL109480 | TANESPIMYCIN | EC50 | = | 64.9 | nM | 7.19 |
| CHEMBL112953 | — | EC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL14830 | ADENOSINE DIPHOSPHATE | EC50 | = | 120000.0 | nM | - |