Assay Detail
Functional
CHEMBL908226
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Inhibition of MDA-MB-231 cell proliferation (mean of two experiments)
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MDA-MB-231 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Identification and optimisation of a series of substituted 5-pyridin-2-yl-thiophene-2-hydroxamic acids as potent histone deacetylase (HDAC) inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 6.19 | 6.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL386914 | — | — | 1 | 6.77 |
| CHEMBL217531 | — | — | 1 | 6.70 |
| CHEMBL217097 | — | — | 1 | 6.68 |
| CHEMBL216884 | — | — | 1 | 6.66 |
| CHEMBL217529 | — | — | 1 | 6.60 |
| CHEMBL387247 | — | — | 1 | 6.52 |
| CHEMBL217881 | — | — | 1 | 6.52 |
| CHEMBL217093 | — | — | 1 | 6.43 |
| CHEMBL263570 | — | — | 1 | 6.20 |
| CHEMBL217716 | — | — | 1 | 6.20 |
| CHEMBL387105 | — | — | 1 | 6.07 |
| CHEMBL425971 | — | — | 1 | 5.46 |
| CHEMBL216509 | — | — | 1 | 4.96 |
| CHEMBL98 | VORINOSTAT | 4.0 | 1 | 4.91 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL386914 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL217531 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL217097 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL216884 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL217529 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL387247 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL217881 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL217093 | — | IC50 | = | 370.0 | nM | 6.43 |
| CHEMBL263570 | — | IC50 | = | 630.0 | nM | 6.20 |
| CHEMBL217716 | — | IC50 | = | 630.0 | nM | 6.20 |
| CHEMBL387105 | — | IC50 | = | 860.0 | nM | 6.07 |
| CHEMBL425971 | — | IC50 | = | 3510.0 | nM | 5.46 |
| CHEMBL216509 | — | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL98 | VORINOSTAT | IC50 | = | 12300.0 | nM | 4.91 |