Assay Detail
Binding
CHEMBL908237
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In vitro inhibition of DPP-4
27
Total Activities
27
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
3-[2-((2S)-2-cyano-pyrrolidin-1-yl)-2-oxo-ethylamino]-3-methyl-butyramide analogues as selective DPP-IV inhibitors for the treatment of type-II diabetes.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 27 | 6.60 | 7.38 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL217245 | — | — | 1 | 7.38 |
| CHEMBL217198 | — | — | 1 | 6.94 |
| CHEMBL218026 | — | — | 1 | 6.93 |
| CHEMBL201158 | — | — | 1 | 6.92 |
| CHEMBL217059 | — | — | 1 | 6.90 |
| CHEMBL274770 | — | — | 1 | 6.84 |
| CHEMBL385394 | — | — | 1 | 6.76 |
| CHEMBL218393 | — | — | 1 | 6.74 |
| CHEMBL216453 | — | — | 1 | 6.72 |
| CHEMBL385637 | — | — | 1 | 6.71 |
| CHEMBL216383 | — | — | 1 | 6.68 |
| CHEMBL386326 | — | — | 1 | 6.65 |
| CHEMBL217290 | — | — | 1 | 6.63 |
| CHEMBL274103 | — | — | 1 | 6.63 |
| CHEMBL216377 | — | — | 1 | 6.62 |
| CHEMBL384493 | — | — | 1 | 6.61 |
| CHEMBL217339 | — | — | 1 | 6.60 |
| CHEMBL384985 | — | — | 1 | 6.60 |
| CHEMBL217060 | — | — | 1 | 6.57 |
| CHEMBL371480 | — | — | 1 | 6.53 |
| CHEMBL216878 | — | — | 1 | 6.50 |
| CHEMBL216296 | — | — | 1 | 6.36 |
| CHEMBL382907 | — | — | 1 | 6.34 |
| CHEMBL201544 | — | — | 1 | 6.25 |
| CHEMBL216203 | — | — | 1 | 6.04 |
| CHEMBL202711 | — | — | 1 | 5.96 |
| CHEMBL217212 | — | — | 1 | 5.89 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL217245 | — | IC50 | = | 42.0 | nM | 7.38 |
| CHEMBL217198 | — | IC50 | = | 116.0 | nM | 6.94 |
| CHEMBL218026 | — | IC50 | = | 118.0 | nM | 6.93 |
| CHEMBL201158 | — | IC50 | = | 119.0 | nM | 6.92 |
| CHEMBL217059 | — | IC50 | = | 127.0 | nM | 6.90 |
| CHEMBL274770 | — | IC50 | = | 144.0 | nM | 6.84 |
| CHEMBL385394 | — | IC50 | = | 174.0 | nM | 6.76 |
| CHEMBL218393 | — | IC50 | = | 181.0 | nM | 6.74 |
| CHEMBL216453 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL385637 | — | IC50 | = | 197.0 | nM | 6.71 |
| CHEMBL216383 | — | IC50 | = | 207.0 | nM | 6.68 |
| CHEMBL386326 | — | IC50 | = | 225.0 | nM | 6.65 |
| CHEMBL217290 | — | IC50 | = | 232.0 | nM | 6.63 |
| CHEMBL274103 | — | IC50 | = | 236.0 | nM | 6.63 |
| CHEMBL216377 | — | IC50 | = | 239.0 | nM | 6.62 |
| CHEMBL384493 | — | IC50 | = | 247.0 | nM | 6.61 |
| CHEMBL217339 | — | IC50 | = | 252.0 | nM | 6.60 |
| CHEMBL384985 | — | IC50 | = | 253.0 | nM | 6.60 |
| CHEMBL217060 | — | IC50 | = | 269.0 | nM | 6.57 |
| CHEMBL371480 | — | IC50 | = | 298.0 | nM | 6.53 |
| CHEMBL216878 | — | IC50 | = | 320.0 | nM | 6.50 |
| CHEMBL216296 | — | IC50 | = | 433.0 | nM | 6.36 |
| CHEMBL382907 | — | IC50 | = | 452.0 | nM | 6.34 |
| CHEMBL201544 | — | IC50 | = | 564.0 | nM | 6.25 |
| CHEMBL216203 | — | IC50 | = | 911.0 | nM | 6.04 |
| CHEMBL202711 | — | IC50 | = | 1108.0 | nM | 5.96 |
| CHEMBL217212 | — | IC50 | = | 1300.0 | nM | 5.89 |