Assay Detail
Binding
CHEMBL908251
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Inhibition of DPP-IV
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Discovery of non-covalent dipeptidyl peptidase IV inhibitors which induce a conformational change in the active site.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 6.55 | 8.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL541664 | — | — | 1 | 8.30 |
| CHEMBL217017 | — | — | 1 | 7.41 |
| CHEMBL218289 | — | — | 1 | 7.08 |
| CHEMBL554090 | — | — | 1 | 6.96 |
| CHEMBL217388 | — | — | 1 | 6.55 |
| CHEMBL553006 | — | — | 1 | 6.47 |
| CHEMBL217801 | — | — | 1 | 6.09 |
| CHEMBL217532 | — | — | 1 | 5.42 |
| CHEMBL386895 | — | — | 1 | 4.68 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL541664 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL217017 | — | IC50 | = | 39.0 | nM | 7.41 |
| CHEMBL218289 | — | IC50 | = | 84.0 | nM | 7.08 |
| CHEMBL554090 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL217388 | — | IC50 | = | 280.0 | nM | 6.55 |
| CHEMBL553006 | — | IC50 | = | 340.0 | nM | 6.47 |
| CHEMBL217801 | — | IC50 | = | 820.0 | nM | 6.09 |
| CHEMBL217532 | — | IC50 | = | 3800.0 | nM | 5.42 |
| CHEMBL386895 | — | IC50 | = | 21000.0 | nM | 4.68 |