Assay Detail
Binding
CHEMBL908433
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [125I-alpha]-Bungarotoxin from alpha-7 nAChR in rat hippocampal membranes
7
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Hippocampus |
| Subcellular | Membrane |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Target
Neuronal acetylcholine receptor subunit alpha-7 (CHEMBL4980) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Epibatidine isomers and analogues: structure-activity relationships.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 7 | 7.46 | 8.41 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL185667 | — | — | 2 | 8.41 |
| CHEMBL298517 | (+)-EPIBATIDINE | — | 1 | 8.31 |
| CHEMBL535619 | — | — | 1 | 8.20 |
| CHEMBL298826 | (-)-EPIBATIDINE | — | 1 | 8.15 |
| CHEMBL535389 | (+/-)-HOMOEPIBATIDINE | — | 1 | 7.89 |
| CHEMBL363973 | — | — | 1 | 5.48 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL185667 | — | Ki | = | 3.9 | nM | 8.41 |
| CHEMBL298517 | (+)-EPIBATIDINE | Ki | = | 4.9 | nM | 8.31 |
| CHEMBL535619 | — | Ki | = | 6.3 | nM | 8.20 |
| CHEMBL298826 | (-)-EPIBATIDINE | Ki | = | 7.0 | nM | 8.15 |
| CHEMBL535389 | (+/-)-HOMOEPIBATIDINE | Ki | = | 13.0 | nM | 7.89 |
| CHEMBL185667 | — | Ki | = | 1600.0 | nM | 5.80 |
| CHEMBL363973 | — | Ki | = | 3300.0 | nM | 5.48 |