Assay Detail
Binding
CHEMBL908435
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Inhibition of MMP13
37
Total Activities
37
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Potent, selective pyrimidinetrione-based inhibitors of MMP-13.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 37 | 8.86 | 9.47 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL221480 | — | — | 1 | 9.47 |
| CHEMBL220904 | — | — | 1 | 9.44 |
| CHEMBL220522 | — | — | 1 | 9.40 |
| CHEMBL374041 | — | — | 1 | 9.40 |
| CHEMBL221634 | — | — | 1 | 9.35 |
| CHEMBL222007 | — | — | 1 | 9.34 |
| CHEMBL221632 | — | — | 1 | 9.28 |
| CHEMBL374015 | — | — | 1 | 9.27 |
| CHEMBL386954 | — | — | 1 | 9.24 |
| CHEMBL374770 | — | — | 1 | 9.20 |
| CHEMBL220957 | — | — | 1 | 9.17 |
| CHEMBL221267 | — | — | 1 | 9.14 |
| CHEMBL222077 | — | — | 1 | 9.08 |
| CHEMBL375342 | — | — | 1 | 9.08 |
| CHEMBL375667 | — | — | 1 | 9.08 |
| CHEMBL221806 | — | — | 1 | 9.07 |
| CHEMBL387343 | — | — | 1 | 9.06 |
| CHEMBL374915 | — | — | 1 | 9.03 |
| CHEMBL221497 | — | — | 1 | 9.00 |
| CHEMBL221685 | — | — | 1 | 9.00 |
| CHEMBL221751 | — | — | 1 | 8.96 |
| CHEMBL376859 | — | — | 1 | 8.85 |
| CHEMBL220964 | — | — | 1 | 8.80 |
| CHEMBL376299 | — | — | 1 | 8.77 |
| CHEMBL376010 | — | — | 1 | 8.70 |
| CHEMBL222060 | — | — | 1 | 8.62 |
| CHEMBL221552 | — | — | 1 | 8.59 |
| CHEMBL221379 | — | — | 1 | 8.48 |
| CHEMBL220911 | — | — | 1 | 8.47 |
| CHEMBL218118 | — | — | 1 | 8.47 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL221480 | — | IC50 | = | 0.34 | nM | 9.47 |
| CHEMBL220904 | — | IC50 | = | 0.36 | nM | 9.44 |
| CHEMBL374041 | — | IC50 | = | 0.4 | nM | 9.40 |
| CHEMBL220522 | — | IC50 | = | 0.4 | nM | 9.40 |
| CHEMBL221634 | — | IC50 | = | 0.45 | nM | 9.35 |
| CHEMBL222007 | — | IC50 | = | 0.46 | nM | 9.34 |
| CHEMBL221632 | — | IC50 | = | 0.53 | nM | 9.28 |
| CHEMBL374015 | — | IC50 | = | 0.54 | nM | 9.27 |
| CHEMBL386954 | — | IC50 | = | 0.57 | nM | 9.24 |
| CHEMBL374770 | — | IC50 | = | 0.63 | nM | 9.20 |
| CHEMBL220957 | — | IC50 | = | 0.68 | nM | 9.17 |
| CHEMBL221267 | — | IC50 | = | 0.73 | nM | 9.14 |
| CHEMBL222077 | — | IC50 | = | 0.84 | nM | 9.08 |
| CHEMBL375342 | — | IC50 | = | 0.84 | nM | 9.08 |
| CHEMBL375667 | — | IC50 | = | 0.84 | nM | 9.08 |
| CHEMBL221806 | — | IC50 | = | 0.85 | nM | 9.07 |
| CHEMBL387343 | — | IC50 | = | 0.88 | nM | 9.06 |
| CHEMBL374915 | — | IC50 | = | 0.93 | nM | 9.03 |
| CHEMBL221497 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL221685 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL221751 | — | IC50 | = | 1.1 | nM | 8.96 |
| CHEMBL376859 | — | IC50 | = | 1.4 | nM | 8.85 |
| CHEMBL220964 | — | IC50 | = | 1.6 | nM | 8.80 |
| CHEMBL376299 | — | IC50 | = | 1.7 | nM | 8.77 |
| CHEMBL376010 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL222060 | — | IC50 | = | 2.4 | nM | 8.62 |
| CHEMBL221552 | — | IC50 | = | 2.6 | nM | 8.59 |
| CHEMBL221379 | — | IC50 | = | 3.3 | nM | 8.48 |
| CHEMBL220911 | — | IC50 | = | 3.4 | nM | 8.47 |
| CHEMBL218118 | — | IC50 | = | 3.4 | nM | 8.47 |
| CHEMBL373675 | — | IC50 | = | 3.9 | nM | 8.41 |
| CHEMBL221449 | — | IC50 | = | 6.1 | nM | 8.21 |
| CHEMBL220644 | — | IC50 | = | 6.1 | nM | 8.21 |
| CHEMBL220965 | — | IC50 | = | 7.5 | nM | 8.12 |
| CHEMBL221808 | — | IC50 | = | 7.8 | nM | 8.11 |
| CHEMBL374364 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL375818 | — | IC50 | = | 12.0 | nM | 7.92 |