Assay Detail
Binding
CHEMBL908472
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Displacement of [3H]histamine from human recombinant histamine H4 receptor expressed in SK-N-MC cells
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | SK-N-MC |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Identification of 2-arylbenzimidazoles as potent human histamine H4 receptor ligands.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 10 | 7.56 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL373579 | — | — | 1 | 9.00 |
| CHEMBL219982 | — | — | 1 | 8.05 |
| CHEMBL220933 | — | — | 1 | 7.66 |
| CHEMBL387342 | — | — | 1 | 7.58 |
| CHEMBL221210 | — | — | 1 | 7.58 |
| CHEMBL223490 | — | — | 1 | 7.55 |
| CHEMBL219930 | — | — | 1 | 7.34 |
| CHEMBL221211 | — | — | 1 | 7.19 |
| CHEMBL220934 | — | — | 1 | 7.03 |
| CHEMBL376268 | — | — | 1 | 6.60 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL373579 | — | Ki | = | 1.0 | nM | 9.00 |
| CHEMBL219982 | — | Ki | = | 9.0 | nM | 8.05 |
| CHEMBL220933 | — | Ki | = | 22.0 | nM | 7.66 |
| CHEMBL387342 | — | Ki | = | 26.0 | nM | 7.58 |
| CHEMBL221210 | — | Ki | = | 26.0 | nM | 7.58 |
| CHEMBL223490 | — | Ki | = | 28.0 | nM | 7.55 |
| CHEMBL219930 | — | Ki | = | 46.0 | nM | 7.34 |
| CHEMBL221211 | — | Ki | = | 65.0 | nM | 7.19 |
| CHEMBL220934 | — | Ki | = | 93.0 | nM | 7.03 |
| CHEMBL376268 | — | Ki | = | 250.0 | nM | 6.60 |