Assay Detail
Functional
CHEMBL908546
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Hydroxyl radical scavenging activity by ESR spin-trapping method
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Hydroxyl radical scavenging by edaravone derivatives: Efficient scavenging by 3-methyl-1-(pyridin-2-yl)-5-pyrazolone with an intramolecular base.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 4.75 | 4.75 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL374252 | — | — | 1 | 4.75 |
| CHEMBL376894 | — | — | 1 | - |
| CHEMBL223006 | — | — | 1 | - |
| CHEMBL290916 | EDARAVONE | 4.0 | 1 | - |
| CHEMBL223084 | — | — | 1 | - |
| CHEMBL373456 | — | — | 1 | - |
| CHEMBL373481 | — | — | 1 | - |
| CHEMBL220283 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL374252 | — | IC50 | = | 18000.0 | nM | 4.75 |
| CHEMBL376894 | — | IC50 | = | 380000.0 | nM | - |
| CHEMBL223006 | — | IC50 | = | 810000.0 | nM | - |
| CHEMBL290916 | EDARAVONE | IC50 | = | 250000.0 | nM | - |
| CHEMBL223084 | — | IC50 | = | 790000.0 | nM | - |
| CHEMBL373456 | — | IC50 | = | 720000.0 | nM | - |
| CHEMBL373481 | — | IC50 | = | 610000.0 | nM | - |
| CHEMBL220283 | — | IC50 | = | 500000.0 | nM | - |