Assay Detail
Binding
CHEMBL908626
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [125I]CGRP from human recombinant CGRP receptor
51
Total Activities
51
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Calcitonin gene-related peptide type 1 receptor (CHEMBL3798) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Benzodiazepine calcitonin gene-related peptide (CGRP) receptor antagonists: optimization of the 4-substituted piperidine.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 50 | 6.49 | 8.96 |
| Activity | 1 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL385454 | — | — | 1 | 8.96 |
| CHEMBL215325 | — | — | 1 | 8.20 |
| CHEMBL214507 | — | — | 1 | 7.96 |
| CHEMBL215274 | — | — | 1 | 7.96 |
| CHEMBL215499 | — | — | 1 | 7.96 |
| CHEMBL386757 | — | — | 1 | 7.72 |
| CHEMBL408093 | — | — | 1 | 7.64 |
| CHEMBL384799 | — | — | 1 | 7.58 |
| CHEMBL384539 | — | — | 1 | 7.57 |
| CHEMBL383872 | — | — | 1 | 7.57 |
| CHEMBL213976 | — | — | 1 | 7.54 |
| CHEMBL424864 | — | — | 1 | 7.32 |
| CHEMBL379548 | — | — | 1 | 7.29 |
| CHEMBL437718 | — | — | 1 | 6.98 |
| CHEMBL384408 | — | — | 1 | 6.96 |
| CHEMBL386204 | — | — | 1 | 6.84 |
| CHEMBL211931 | — | — | 1 | 6.81 |
| CHEMBL214800 | — | — | 1 | 6.69 |
| CHEMBL405544 | — | — | 1 | 6.58 |
| CHEMBL212942 | — | — | 1 | 6.53 |
| CHEMBL377252 | — | — | 1 | 6.50 |
| CHEMBL214904 | — | — | 1 | 6.47 |
| CHEMBL427743 | — | — | 1 | 6.46 |
| CHEMBL214873 | — | — | 1 | 6.43 |
| CHEMBL386113 | — | — | 1 | 6.37 |
| CHEMBL214845 | — | — | 1 | 6.24 |
| CHEMBL213670 | — | — | 1 | 6.23 |
| CHEMBL415453 | — | — | 1 | 6.16 |
| CHEMBL214829 | — | — | 1 | 6.14 |
| CHEMBL405543 | — | — | 1 | 6.09 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL385454 | — | Ki | = | 1.1 | nM | 8.96 |
| CHEMBL215325 | — | Ki | = | 6.3 | nM | 8.20 |
| CHEMBL215274 | — | Ki | = | 11.0 | nM | 7.96 |
| CHEMBL215499 | — | Ki | = | 11.0 | nM | 7.96 |
| CHEMBL214507 | — | Ki | = | 11.0 | nM | 7.96 |
| CHEMBL386757 | — | Ki | = | 19.0 | nM | 7.72 |
| CHEMBL408093 | — | Ki | = | 23.0 | nM | 7.64 |
| CHEMBL384799 | — | Ki | = | 26.0 | nM | 7.58 |
| CHEMBL384539 | — | Ki | = | 27.0 | nM | 7.57 |
| CHEMBL383872 | — | Ki | = | 27.0 | nM | 7.57 |
| CHEMBL213976 | — | Ki | = | 29.0 | nM | 7.54 |
| CHEMBL424864 | — | Ki | = | 48.0 | nM | 7.32 |
| CHEMBL379548 | — | Ki | = | 51.0 | nM | 7.29 |
| CHEMBL437718 | — | Ki | = | 104.0 | nM | 6.98 |
| CHEMBL384408 | — | Ki | = | 110.0 | nM | 6.96 |
| CHEMBL386204 | — | Ki | = | 143.0 | nM | 6.84 |
| CHEMBL211931 | — | Ki | = | 156.0 | nM | 6.81 |
| CHEMBL214800 | — | Ki | = | 205.0 | nM | 6.69 |
| CHEMBL405544 | — | Ki | = | 260.0 | nM | 6.58 |
| CHEMBL212942 | — | Ki | = | 295.0 | nM | 6.53 |
| CHEMBL377252 | — | Ki | = | 320.0 | nM | 6.50 |
| CHEMBL214904 | — | Ki | = | 339.0 | nM | 6.47 |
| CHEMBL427743 | — | Ki | = | 350.0 | nM | 6.46 |
| CHEMBL214873 | — | Ki | = | 375.0 | nM | 6.43 |
| CHEMBL386113 | — | Ki | = | 427.0 | nM | 6.37 |
| CHEMBL214845 | — | Ki | = | 575.0 | nM | 6.24 |
| CHEMBL213670 | — | Ki | = | 583.0 | nM | 6.23 |
| CHEMBL415453 | — | Ki | = | 685.0 | nM | 6.16 |
| CHEMBL214829 | — | Ki | = | 720.0 | nM | 6.14 |
| CHEMBL405543 | — | Ki | = | 810.0 | nM | 6.09 |
| CHEMBL384723 | — | Ki | = | 853.0 | nM | 6.07 |
| CHEMBL425807 | — | Ki | = | 855.0 | nM | 6.07 |
| CHEMBL215424 | — | Ki | = | 965.0 | nM | 6.01 |
| CHEMBL426142 | — | Ki | = | 983.0 | nM | 6.01 |
| CHEMBL214950 | — | Ki | = | 1000.0 | nM | 6.00 |
| CHEMBL443577 | — | Ki | = | 1050.0 | nM | 5.98 |
| CHEMBL386714 | — | Ki | = | 1055.0 | nM | 5.98 |
| CHEMBL386701 | — | Ki | = | 1125.0 | nM | 5.95 |
| CHEMBL384409 | — | Ki | = | 2000.0 | nM | 5.70 |
| CHEMBL381798 | — | Ki | = | 2250.0 | nM | 5.65 |
| CHEMBL386706 | — | Ki | = | 2800.0 | nM | 5.55 |
| CHEMBL384091 | — | Ki | = | 2900.0 | nM | 5.54 |
| CHEMBL375872 | — | Ki | = | 3800.0 | nM | 5.42 |
| CHEMBL385399 | — | Ki | = | 5337.0 | nM | 5.27 |
| CHEMBL214751 | — | Ki | = | 6100.0 | nM | 5.21 |
| CHEMBL384565 | — | Ki | = | 6400.0 | nM | 5.19 |
| CHEMBL384080 | — | Ki | = | 6900.0 | nM | 5.16 |
| CHEMBL215549 | — | Ki | = | 20000.0 | nM | 4.70 |
| CHEMBL213717 | — | Ki | = | 20000.0 | nM | 4.70 |
| CHEMBL384772 | — | Activity | - | — | - |