Assay Detail
Functional
CHEMBL908795
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of MCF7 cell proliferation (mean of two experiments)
25
Total Activities
25
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MCF7 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Identification and optimisation of a series of substituted 5-(1H-pyrazol-3-yl)-thiophene-2-hydroxamic acids as potent histone deacetylase (HDAC) inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 25 | 6.48 | 7.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL217004 | — | — | 1 | 7.22 |
| CHEMBL386473 | — | — | 1 | 7.22 |
| CHEMBL218511 | — | — | 1 | 7.10 |
| CHEMBL216249 | — | — | 1 | 7.00 |
| CHEMBL426343 | — | — | 1 | 6.92 |
| CHEMBL385406 | — | — | 1 | 6.92 |
| CHEMBL216248 | — | — | 1 | 6.85 |
| CHEMBL217186 | — | — | 1 | 6.85 |
| CHEMBL385852 | — | — | 1 | 6.82 |
| CHEMBL216625 | — | — | 1 | 6.77 |
| CHEMBL217098 | — | — | 1 | 6.72 |
| CHEMBL384961 | — | — | 1 | 6.70 |
| CHEMBL217716 | — | — | 1 | 6.52 |
| CHEMBL217468 | — | — | 1 | 6.46 |
| CHEMBL386752 | — | — | 1 | 6.43 |
| CHEMBL386135 | — | — | 1 | 6.34 |
| CHEMBL216499 | — | — | 1 | 6.33 |
| CHEMBL218514 | — | — | 1 | 6.30 |
| CHEMBL218080 | — | — | 1 | 6.28 |
| CHEMBL217029 | — | — | 1 | 6.10 |
| CHEMBL216359 | — | — | 1 | 5.91 |
| CHEMBL98 | VORINOSTAT | 4.0 | 1 | 5.82 |
| CHEMBL217604 | — | — | 1 | 5.80 |
| CHEMBL218236 | — | — | 1 | 5.69 |
| CHEMBL216885 | — | — | 1 | 4.94 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL217004 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL386473 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL218511 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL216249 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL426343 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL385406 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL216248 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL217186 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL385852 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL216625 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL217098 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL384961 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL217716 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL217468 | — | IC50 | = | 350.0 | nM | 6.46 |
| CHEMBL386752 | — | IC50 | = | 370.0 | nM | 6.43 |
| CHEMBL386135 | — | IC50 | = | 460.0 | nM | 6.34 |
| CHEMBL216499 | — | IC50 | = | 470.0 | nM | 6.33 |
| CHEMBL218514 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL218080 | — | IC50 | = | 520.0 | nM | 6.28 |
| CHEMBL217029 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL216359 | — | IC50 | = | 1240.0 | nM | 5.91 |
| CHEMBL98 | VORINOSTAT | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL217604 | — | IC50 | = | 1580.0 | nM | 5.80 |
| CHEMBL218236 | — | IC50 | = | 2060.0 | nM | 5.69 |
| CHEMBL216885 | — | IC50 | = | 11400.0 | nM | 4.94 |