Assay Detail
Functional
CHEMBL908798
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Inhibition of MDA-MB-231 cell proliferation (mean of two experiments)
25
Total Activities
25
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MDA-MB-231 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Identification and optimisation of a series of substituted 5-(1H-pyrazol-3-yl)-thiophene-2-hydroxamic acids as potent histone deacetylase (HDAC) inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 25 | 5.99 | 6.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL217004 | — | — | 1 | 6.92 |
| CHEMBL386473 | — | — | 1 | 6.70 |
| CHEMBL426343 | — | — | 1 | 6.64 |
| CHEMBL218511 | — | — | 1 | 6.55 |
| CHEMBL216249 | — | — | 1 | 6.52 |
| CHEMBL217186 | — | — | 1 | 6.52 |
| CHEMBL216625 | — | — | 1 | 6.43 |
| CHEMBL385852 | — | — | 1 | 6.28 |
| CHEMBL384961 | — | — | 1 | 6.26 |
| CHEMBL217098 | — | — | 1 | 6.25 |
| CHEMBL217716 | — | — | 1 | 6.20 |
| CHEMBL216248 | — | — | 1 | 6.16 |
| CHEMBL217468 | — | — | 1 | 6.12 |
| CHEMBL385406 | — | — | 1 | 6.08 |
| CHEMBL216499 | — | — | 1 | 5.82 |
| CHEMBL218514 | — | — | 1 | 5.82 |
| CHEMBL217029 | — | — | 1 | 5.82 |
| CHEMBL386135 | — | — | 1 | 5.75 |
| CHEMBL386752 | — | — | 1 | 5.70 |
| CHEMBL218080 | — | — | 1 | 5.66 |
| CHEMBL216359 | — | — | 1 | 5.54 |
| CHEMBL217604 | — | — | 1 | 5.35 |
| CHEMBL218236 | — | — | 1 | 5.34 |
| CHEMBL98 | VORINOSTAT | 4.0 | 1 | 4.91 |
| CHEMBL216885 | — | — | 1 | 4.50 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL217004 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL386473 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL426343 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL218511 | — | IC50 | = | 280.0 | nM | 6.55 |
| CHEMBL216249 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL217186 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL216625 | — | IC50 | = | 370.0 | nM | 6.43 |
| CHEMBL385852 | — | IC50 | = | 530.0 | nM | 6.28 |
| CHEMBL384961 | — | IC50 | = | 550.0 | nM | 6.26 |
| CHEMBL217098 | — | IC50 | = | 560.0 | nM | 6.25 |
| CHEMBL217716 | — | IC50 | = | 630.0 | nM | 6.20 |
| CHEMBL216248 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL217468 | — | IC50 | = | 750.0 | nM | 6.12 |
| CHEMBL385406 | — | IC50 | = | 840.0 | nM | 6.08 |
| CHEMBL216499 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL218514 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL217029 | — | IC50 | = | 1510.0 | nM | 5.82 |
| CHEMBL386135 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL386752 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL218080 | — | IC50 | = | 2190.0 | nM | 5.66 |
| CHEMBL216359 | — | IC50 | = | 2910.0 | nM | 5.54 |
| CHEMBL217604 | — | IC50 | = | 4500.0 | nM | 5.35 |
| CHEMBL218236 | — | IC50 | = | 4540.0 | nM | 5.34 |
| CHEMBL98 | VORINOSTAT | IC50 | = | 12300.0 | nM | 4.91 |
| CHEMBL216885 | — | IC50 | = | 31500.0 | nM | 4.50 |